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Gene Review:

CBLC - Cbl proto-oncogene C, E3 ubiquitin protein...

Homo sapiens

Synonyms: CBL-3, CBL-SL, CBL3, E3 ubiquitin-protein ligase CBL-C, RING finger protein 57, ...

Soon-Shiong, P. et al., Kohout, S.C. et al., Courbard, J.R. et al., Floyd, D.N. et al., Minde, K. et al.

Minde, Eakin, Hechtman, Ochs, Bouffard, Greenfield, Looper,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on CBLC

Children were screened for ADHD and other problems, using the C-DISC, CBLC, TRF and the Social Adjustment Inventory [1].

High impact information on CBLC

Among the three CBL proteins described in humans, CBLC (CBL3) remains poorly studied [2].
Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH [2].
Positive membrane depth parameters indicative of membrane insertion were found for three positions, all located on the Ca(2+) binding loops: N189 on CBL 1, and both R249 and R252 on CBL 3 [3].
These properties allow isolated human islets to be identified by fluorescein isothiocyanate-labeled CBL3 and TT62, making these monoclonal antibodies potentially useful reagents in islet identification and purification [4].

Anatomical context of CBLC

At 4 Gy, CBL1 (P < 0.001), CBL2 (P < 0.05), CBL3 (P < 0.01) and CBL5 (P < 0.01) were more radiosensitive than the mean radiosensitivity of the adult lymphocytes [5].

References

The psychosocial functioning of children and spouses of adults with ADHD. Minde, K., Eakin, L., Hechtman, L., Ochs, E., Bouffard, R., Greenfield, B., Looper, K. Journal of child psychology and psychiatry, and allied disciplines. (2003) [Pubmed]
Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH. Courbard, J.R., Fiore, F., Adélaïde, J., Borg, J.P., Birnbaum, D., Ollendorff, V. J. Biol. Chem. (2002) [Pubmed]
C2 domain of protein kinase C alpha: elucidation of the membrane docking surface by site-directed fluorescence and spin labeling. Kohout, S.C., Corbalán-García, S., Gómez-Fernández, J.C., Falke, J.J. Biochemistry (2003) [Pubmed]
Characterization of monoclonal antibodies CBL3 and TT62 with differing antigenic determinants specific for isolated human islets. Soon-Shiong, P., Heintz, R., Terasaki, P. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
Intrinsic radiosensitivity of adult and cord blood lymphocytes as determined by the micronucleus assay. Floyd, D.N., Cassoni, A.M. Eur. J. Cancer (1994) [Pubmed]

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