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Gene Review

Cblc  -  Casitas B-lineage lymphoma c

Mus musculus

Synonyms: 2310076I21Rik, 2310079L19Rik, Cbl3, E3 ubiquitin-protein ligase CBL-C, SH3-binding protein CBL-3, ...
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High impact information on Cblc

  • Proliferation of epithelial cells in the epidermises and gastrointestinal tracts was unaffected by the loss of Cbl-3 [1].
  • Cbl-3 expression was not detected in nonepithelial cells, but within epithelial tissues, the levels of Cbl-3 expression varied from undetectable in the alveoli of the lungs to very strong in the cecum and colon [1].
  • Here we show that Cbl-b, but not Cbl-3, utilize the same mechanism to down-regulate multiple RTKs [2].


  1. Cbl-3-deficient mice exhibit normal epithelial development. Griffiths, E.K., Sanchez, O., Mill, P., Krawczyk, C., Hojilla, C.V., Rubin, E., Nau, M.M., Khokha, R., Lipkowitz, S., Hui, C.C., Penninger, J.M. Mol. Cell. Biol. (2003) [Pubmed]
  2. CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. Szymkiewicz, I., Kowanetz, K., Soubeyran, P., Dinarina, A., Lipkowitz, S., Dikic, I. J. Biol. Chem. (2002) [Pubmed]
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