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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Olfml1  -  olfactomedin-like 1

Mus musculus

Synonyms: 6720478C22, AV321997, BC047207, MVAL564, ONT2, ...
 
 
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High impact information on Olfml1

  • In conclusion, we have identified a novel PU.1-regulated extracellular glycoprotein of the olfactomedin-like family with a possible role in neutrophilic trafficking [1].
  • The pDP4 gene encodes a secreted 57-kDa glycoprotein with an olfactomedin-like C-terminus [1].
  • Expanded by a plausible gene duplication and domain couplings scenario, the OLF family comprises seven evolutionarily and functionally distinct subfamilies, in which each member shares similar structural and functional characteristics including the composition of coevolved and interdependent domains [2].
  • Elucidation of subfamily segregation and intramolecular coevolution of the olfactomedin-like proteins by comprehensive phylogenetic analysis and gene expression pattern assessment [2].
 

Analytical, diagnostic and therapeutic context of Olfml1

  • Furthermore, our Northern blot analysis and previous studies revealed that the typical human OLF members in each subfamily exhibited tissue-specific expression patterns, which in turn supported the segregation of the OLF subfamilies with functional divergence [2].

References

  1. pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1. Rosenbauer, F., Wagner, K., Zhang, P., Knobeloch, K.P., Iwama, A., Tenen, D.G. Blood (2004) [Pubmed]
  2. Elucidation of subfamily segregation and intramolecular coevolution of the olfactomedin-like proteins by comprehensive phylogenetic analysis and gene expression pattern assessment. Zeng, L.C., Han, Z.G., Ma, W.J. FEBS Lett. (2005) [Pubmed]
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