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Gene Review:

DEFB106A - defensin, beta 106A

Homo sapiens

Synonyms: BD-6, DEFB-6, DEFB106

Kao, C.Y. et al., Bicknell, D.C. et al., Balansky, R. et al., Yamaguchi, Y. et al., Li, H. et al.

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High impact information on DEFB106A

The predicted peptides conserve the six-cysteine motif identical with hBD-4, termed hBD-5 and hBD-6 [1].
Two of them, DEFB106 and DEFB109, were expressed in the lung [2].
This treatment significantly inhibited, by 26.2-28.6% and by 34.2%, the total intestinal carcinogenesis induced by 1,2-dimethylhydrazine (DMH, 21 mg/kg, s.c., once per week for 20 weeks) in male and female BD6 rats, respectively [3].
Lipid content of BD1, BD5 and BD6 was also significantly higher than that of AS [4].
Four monoclonal antibodies, 5/138, 5/32, BD6 and 6/266, are reported which recognize a previously described membrane associated dimeric protein of Mr = 2 X 75,000 and whose expression is correlated with malignant phenotype in HeLa-normal fibroblast hybrids [5].

Analytical, diagnostic and therapeutic context of DEFB106A

A pilot study with cRNA probes for in situ hybridization and a synthetic propeptide for the functional characterization demonstrated the tissue-/cell-specific expression and the strong antimicrobial activity of DEFB106 [2].

References

Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. Yamaguchi, Y., Nagase, T., Makita, R., Fukuhara, S., Tomita, T., Tominaga, T., Kurihara, H., Ouchi, Y. J. Immunol. (2002) [Pubmed]
ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes. Kao, C.Y., Chen, Y., Zhao, Y.H., Wu, R. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
Inhibitory effects of freeze-dried milk fermented by selected Lactobacillus bulgaricus strains on carcinogenesis induced by 1,2-dimethylhydrazine in rats and by diethylnitrosamine in hamsters. Balansky, R., Gyosheva, B., Ganchev, G., Mircheva, Z., Minkova, S., Georgiev, G. Cancer Lett. (1999) [Pubmed]
Nutritional evaluation of different bacterial douchi. Li, H., Feng, F.Q., Shen, L.R., Xie, Y., Li, D. Asia Pacific journal of clinical nutrition (2007) [Pubmed]
Monoclonal antibodies specific for a tumor-associated membrane phosphoprotein in human cell hybrids. Bicknell, D.C., Sutherland, D.R., Stanbridge, E.J., Greaves, M.F. Hybridoma (1985) [Pubmed]

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