The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DEFB106A  -  defensin, beta 106A

Homo sapiens

Synonyms: BD-6, DEFB-6, DEFB106
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on DEFB106A

  • The predicted peptides conserve the six-cysteine motif identical with hBD-4, termed hBD-5 and hBD-6 [1].
  • Two of them, DEFB106 and DEFB109, were expressed in the lung [2].
  • This treatment significantly inhibited, by 26.2-28.6% and by 34.2%, the total intestinal carcinogenesis induced by 1,2-dimethylhydrazine (DMH, 21 mg/kg, s.c., once per week for 20 weeks) in male and female BD6 rats, respectively [3].
  • Lipid content of BD1, BD5 and BD6 was also significantly higher than that of AS [4].
  • Four monoclonal antibodies, 5/138, 5/32, BD6 and 6/266, are reported which recognize a previously described membrane associated dimeric protein of Mr = 2 X 75,000 and whose expression is correlated with malignant phenotype in HeLa-normal fibroblast hybrids [5].

Analytical, diagnostic and therapeutic context of DEFB106A

  • A pilot study with cRNA probes for in situ hybridization and a synthetic propeptide for the functional characterization demonstrated the tissue-/cell-specific expression and the strong antimicrobial activity of DEFB106 [2].


  1. Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. Yamaguchi, Y., Nagase, T., Makita, R., Fukuhara, S., Tomita, T., Tominaga, T., Kurihara, H., Ouchi, Y. J. Immunol. (2002) [Pubmed]
  2. ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes. Kao, C.Y., Chen, Y., Zhao, Y.H., Wu, R. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  3. Inhibitory effects of freeze-dried milk fermented by selected Lactobacillus bulgaricus strains on carcinogenesis induced by 1,2-dimethylhydrazine in rats and by diethylnitrosamine in hamsters. Balansky, R., Gyosheva, B., Ganchev, G., Mircheva, Z., Minkova, S., Georgiev, G. Cancer Lett. (1999) [Pubmed]
  4. Nutritional evaluation of different bacterial douchi. Li, H., Feng, F.Q., Shen, L.R., Xie, Y., Li, D. Asia Pacific journal of clinical nutrition (2007) [Pubmed]
  5. Monoclonal antibodies specific for a tumor-associated membrane phosphoprotein in human cell hybrids. Bicknell, D.C., Sutherland, D.R., Stanbridge, E.J., Greaves, M.F. Hybridoma (1985) [Pubmed]
WikiGenes - Universities