Gene Review:
DEFB1 - defensin, beta 1
Homo sapiens
Synonyms:
BD-1, BD1, Beta-defensin 1, DEFB-1, DEFB101, ...
Levy,
Raby,
Lake,
Tantisira,
Kwiatkowski,
Lazarus,
Silverman,
Richter,
Klimecki,
Vercelli,
Martinez,
Weiss,
Jurevic,
Chrisman,
Mancl,
Livingston,
Dale,
Paulsen,
Pufe,
Conradi,
Varoga,
Tsokos,
Papendieck,
Petersen,
Chong,
Xiang,
Wang,
Jun,
Xi,
Schweinfurth,
Jurevic,
Bai,
Chadwick,
White,
Dale,
Kreuter,
Hyun,
Skrygan,
Sommer,
Bastian,
Altmeyer,
Gambichler,
Meyer,
Schwaab,
Beier,
Görögh,
Buchelt,
Frese,
Maune,
Starner,
Agerberth,
Gudmundsson,
McCray,
Terai,
Sano,
Kawasaki,
Endo,
Adachi,
Hiratsuka,
Ihiboshi,
Nakazato,
Kinoshita,
Klüver,
Schulz,
Forssmann,
Adermann,
Malik,
Al-Kafaji,
- Cancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas. Donald, C.D., Sun, C.Q., Lim, S.D., Macoska, J., Cohen, C., Amin, M.B., Young, A.N., Ganz, T.A., Marshall, F.F., Petros, J.A. Lab. Invest. (2003)
- High level expression of human epithelial beta-defensins (hBD-1, 2 and 3) in papillomavirus induced lesions. Chong, K.T., Xiang, L., Wang, X., Jun, E.L., Xi, L.F., Schweinfurth, J.M. Virol. J. (2006)
- Significance of human beta-defensins in the epithelial lining fluid of patients with chronic lower respiratory tract infections. Yanagi, S., Ashitani, J., Imai, K., Kyoraku, Y., Sano, A., Matsumoto, N., Nakazato, M. Clin. Microbiol. Infect. (2007)
- Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree. Harada, K., Ohba, K., Ozaki, S., Isse, K., Hirayama, T., Wada, A., Nakanuma, Y. Hepatology (2004)
- Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia. Mansour, H.A., Wood, J., Logue, T., Chowdari, K.V., Dayal, M., Kupfer, D.J., Monk, T.H., Devlin, B., Nimgaonkar, V.L. Genes Brain Behav. (2006)
- Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Goldman, M.J., Anderson, G.M., Stolzenberg, E.D., Kari, U.P., Zasloff, M., Wilson, J.M. Cell (1997)
- Immortalization of human T lymphocytes after transfection of Epstein-Barr virus DNA. Stevenson, M., Volsky, B., Hedenskog, M., Volsky, D.J. Science (1986)
- Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. Bals, R., Wang, X., Wu, Z., Freeman, T., Bafna, V., Zasloff, M., Wilson, J.M. J. Clin. Invest. (1998)
- Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. Valore, E.V., Park, C.H., Quayle, A.J., Wiles, K.R., McCray, P.B., Ganz, T. J. Clin. Invest. (1998)
- Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue. Krisanaprakornkit, S., Weinberg, A., Perez, C.N., Dale, B.A. Infect. Immun. (1998)
- Glucose regulation of beta-defensin-1 mRNA in human renal cells. Malik, A.N., Al-Kafaji, G. Biochem. Biophys. Res. Commun. (2007)
- Structural analysis of human beta-defensin-1 and its significance in urinary tract infection. Hiratsuka, T., Nakazato, M., Ihi, T., Minematsu, T., Chino, N., Nakanishi, T., Shimizu, A., Kangawa, K., Matsukura, S. Nephron (2000)
- Association of defensin beta-1 gene polymorphisms with asthma. Levy, H., Raby, B.A., Lake, S., Tantisira, K.G., Kwiatkowski, D., Lazarus, R., Silverman, E.K., Richter, B., Klimecki, W.T., Vercelli, D., Martinez, F.D., Weiss, S.T. J. Allergy Clin. Immunol. (2005)
- Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: high-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls. Jurevic, R.J., Bai, M., Chadwick, R.B., White, T.C., Dale, B.A. J. Clin. Microbiol. (2003)
- Single-nucleotide polymorphisms and haplotype analysis in beta-defensin genes in different ethnic populations. Jurevic, R.J., Chrisman, P., Mancl, L., Livingston, R., Dale, B.A. Genet. Test. (2002)
- Antimicrobial peptides are present in immune and host defense cells of the human respiratory and gastroinstestinal tracts. Wah, J., Wellek, A., Frankenberger, M., Unterberger, P., Welsch, U., Bals, R. Cell Tissue Res. (2006)
- Correlation between beta-defensin expression and induction profiles in gingival keratinocytes. Joly, S., Organ, C.C., Johnson, G.K., McCray, P.B., Guthmiller, J.M. Mol. Immunol. (2005)
- Human {alpha}- and beta-Defensins Block Multiple Steps in Herpes Simplex Virus Infection. Hazrati, E., Galen, B., Lu, W., Wang, W., Ouyang, Y., Keller, M.J., Lehrer, R.I., Herold, B.C. J. Immunol. (2006)
- Use of human reconstructed epidermis to analyze the regulation of beta-defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS. Chadebech, P., Goidin, D., Jacquet, C., Viac, J., Schmitt, D., Staquet, M.J. Cell Biol. Toxicol. (2003)
- Structural and functional characterization of hBD-1(Ser35), a peptide deduced from a DEFB1 polymorphism. Circo, R., Skerlavaj, B., Gennaro, R., Amoroso, A., Zanetti, M. Biochem. Biophys. Res. Commun. (2002)
- Expression and activity of beta-defensins and LL-37 in the developing human lung. Starner, T.D., Agerberth, B., Gudmundsson, G.H., McCray, P.B. J. Immunol. (2005)
- Studies of the biological properties of human beta-defensin 1. Pazgier, M., Prahl, A., Hoover, D.M., Lubkowski, J. J. Biol. Chem. (2007)
- Effects of dexamethasone and cyclosporin A on human beta-defensin in corneal epithelial cells. Terai, K., Sano, Y., Kawasaki, S., Endo, K., Adachi, W., Hiratsuka, T., Ihiboshi, H., Nakazato, M., Kinoshita, S. Exp. Eye Res. (2004)
- The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. Schibli, D.J., Hunter, H.N., Aseyev, V., Starner, T.D., Wiencek, J.M., McCray, P.B., Tack, B.F., Vogel, H.J. J. Biol. Chem. (2002)
- Distribution of human beta-defensin polymorphisms in various control and cystic fibrosis populations. Vankeerberghen, A., Scudiero, O., De Boeck, K., Macek, M., Pignatti, P.F., Van Hul, N., Nuytten, H., Salvatore, F., Castaldo, G., Zemkova, D., Vavrova, V., Cassiman, J.J., Cuppens, H. Genomics (2005)
- Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes. Paulsen, F., Pufe, T., Conradi, L., Varoga, D., Tsokos, M., Papendieck, J., Petersen, W. J. Pathol. (2002)
- Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Duits, L.A., Ravensbergen, B., Rademaker, M., Hiemstra, P.S., Nibbering, P.H. Immunology (2002)
- Ultraviolet A1-induced downregulation of human beta-defensins and interleukin-6 and interleukin-8 correlates with clinical improvement in localized scleroderma. Kreuter, A., Hyun, J., Skrygan, M., Sommer, A., Bastian, A., Altmeyer, P., Gambichler, T. Br. J. Dermatol. (2006)
- Chemical synthesis of beta-defensins and LEAP-1/hepcidin. Klüver, E., Schulz, A., Forssmann, W.G., Adermann, K. J. Pept. Res. (2002)
- Increased concentrations of human beta-defensins in plasma and bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis. Hiratsuka, T., Mukae, H., Iiboshi, H., Ashitani, J., Nabeshima, K., Minematsu, T., Chino, N., Ihi, T., Kohno, S., Nakazato, M. Thorax (2003)
- Association between human beta defensin expression and cholesteatoma formation. Meyer, J.E., Schwaab, M., Beier, U.H., Görögh, T., Buchelt, T., Frese, K., Maune, S. Auris, nasus, larynx. (2006)
- Production of beta-defensin antimicrobial peptides by maxillary sinus mucosa. Carothers, D.G., Graham, S.M., Jia, H.P., Ackermann, M.R., Tack, B.F., McCray, P.B. American journal of rhinology. (2001)