Gene Review:
bty - bloodthirsty
Danio rerio
Synonyms:
SO:0000704
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High impact information on bty
- Whole-mount in situ hybridization of zebrafish embryos showed that bty mRNA was present throughout development and, after the mid-blastula transition, was expressed in the head and in or near the site of primitive erythropoiesis in the tail just prior to red cell production [1].
- The morphant phenotype was rescued by co-injection of synthetic bty mRNA containing an artificial 5'-untranslated region (UTR) with the antisense MO that bound the 5'-UTR of the wild-type bty transcript [1].
- To test the function of bty, we cloned the orthologous zebrafish gene from a kidney cDNA library [1].
- We conclude that bty is likely to play a role in differentiation of the committed red cell progenitor [1].
- One- to four-cell embryos injected with two distinct antisense morpholino oligonucleotides (MOs) targeted to the 5'-end of the bty mRNA failed to develop red cells, whereas embryos injected with 4- and 5-bp mismatch control MOs produced wild-type quantities of erythrocytes [1].
References
- bloodthirsty, an RBCC/TRIM gene required for erythropoiesis in zebrafish. Yergeau, D.A., Cornell, C.N., Parker, S.K., Zhou, Y., Detrich, H.W. Dev. Biol. (2005) [Pubmed]
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