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Gene Review

Myo5b  -  myosin Vb

Rattus norvegicus

Synonyms: Myosin heavy chain myr 6, Unconventional myosin-Vb
 
 
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High impact information on Myo5b

  • Inhibition of the sensitized mutant causes inhibition of accumulation of transferrin in the cytoplasm and increases levels of plasma-membrane transferrin receptor, suggesting that myosin Vb functions in traffic between peripheral and pericentrosomal compartments [1].
  • Expression of the C-terminal tail of myosin Vb, a Rab11a effector, enhances M4 accumulation in perinuclear endosomes [2].
  • Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor [2].

References

  1. Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Provance, D.W., Gourley, C.R., Silan, C.M., Cameron, L.C., Shokat, K.M., Goldenring, J.R., Shah, K., Gillespie, P.G., Mercer, J.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor. Volpicelli, L.A., Lah, J.J., Fang, G., Goldenring, J.R., Levey, A.I. J. Neurosci. (2002) [Pubmed]
 
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