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Gene Review

Rab11a  -  RAB11a, member RAS oncogene family

Rattus norvegicus

Synonyms: 24KG, Rab-11, Rab11, Ras-related protein Rab-11A
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High impact information on Rab11a

  • Rip11 is enriched in polarized epithelial cells where, like Rab11, it is localized to subapical recycling endosomes (ARE) and the apical plasma membrane [1].
  • Rab11 is a GTPase that regulates endosomal trafficking to apical plasma membrane domains in polarized epithelial cells [1].
  • Rip11 is recruited to ARE by binding to Rab11 as well as through a Mg(2+)-dependent interaction of its C2 domain with neutral phospholipids [1].
  • Resensitization was minimally affected by inhibition of vacuolar H(+)-ATPase and phosphatases but was markedly suppressed by disruption of Rab4a and Rab11a [2].
  • Taken together, these results suggest that the context within which a CXXX sequence occurs may also critically control the modification of a protein by prenylation, and that the Rab5 and Rab11 carboxyl termini do not possess conventional CXXX sequences [3].

Biological context of Rab11a

  • The cloning was accomplished using polymerase chain reaction amplified with a set of oligonucleotide primers which were designed from the partial amino acid sequences for 24KG [4].
  • We have isolated cDNA clones from a rat liver cDNA library that encode a ras p21-like small GTP-binding protein (24KG) which was purified from the microsomes-Golgi complex fraction of the rat liver [4].
  • Among the Rab proteins tested, we found that besides the previously described Rab3 proteins, only members of the Rab11 family (Rab11a, 11b, and 25) impaired Ca2+-induced exocytosis [5].
  • Because small GTP-binding proteins of Rab family have been implicated as key regulators of membrane and protein trafficking in mammalian cells, this study was designed to test if ethanol-impaired pituitary FSH and LH secretion is associated with changes in Rab proteins, particularly Rab1B, Rab3B, Rab6, and Rab11 [6].

Anatomical context of Rab11a

  • The 1.0-kilobase 24KG mRNA corresponding to the isolated cDNA was also detected in various rat tissues, such as brain, testis, spleen, and heart [4].
  • In vivo insulin treatment resulted in the recruitment of Rab11 from the microsomal fraction to the plasma membrane [7].
  • RESULTS: The Rab11 protein was identified as a major component of the GTP-binding fraction and its expression in rat cardiac muscle was confirmed [7].
  • Membrane marker enzyme, 5' nucleotidase activity, and the early and recycling endosome markers Rab4 and Rab11 were used to verify the enrichment of these fractions [8].
  • Rab11a is a member of this GTP hydrolyzing protein class and acts as a mediator of insulin stimulated translocation of the glucose transporter GLUT4 in peripheral tissues including heart and skeletal muscle [9].

Associations of Rab11a with chemical compounds

  • This Mr weight was similar to that of the purified 24KG estimated by sodium dodecyl sulfate polyacrylamide gel electrophoresis [4].
  • We suggest that Rab11 is involved in the endosomal recycling, sorting and exocytotic movement of the glucose transporter [7].
  • We therefore conclude that the glutamine residue of Rab11a at position 70 is not strictly essential for GTPase activity of this protein in contrast to Ras and other Rab proteins [9].
  • Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor [10].
  • Tf and TfRs accumulated in centrally located, Rab11-positive vesicles indicating that CI-976 inhibits export of cargo from the central endocytic recycling compartment [11].

Other interactions of Rab11a

  • Most of the intracellular pool of Rab11 overlapped with the high-density GLUT4 pool and most of the transferrin receptor pool [7].
  • Expression of the C-terminal tail of myosin Vb, a Rab11a effector, enhances M4 accumulation in perinuclear endosomes [10].
  • Identification of Rab GTPases 4, 5, 18, and 21 (associated with early endosomes); Rab7 (late endosomes); and Rab11 and Rab25 (recycling endosomes) indicate that a substantial fraction of intracellular AQP2 is present in endosomal compartments [12].
  • Rab11 and possibly VAMP2 may be concentrated in the same relocating foci [13].

Analytical, diagnostic and therapeutic context of Rab11a


  1. A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. Prekeris, R., Klumperman, J., Scheller, R.H. Mol. Cell (2000) [Pubmed]
  2. Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases. Roosterman, D., Cottrell, G.S., Schmidlin, F., Steinhoff, M., Bunnett, N.W. J. Biol. Chem. (2004) [Pubmed]
  3. The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity. Cox, A.D., Graham, S.M., Solski, P.A., Buss, J.E., Der, C.J. J. Biol. Chem. (1993) [Pubmed]
  4. Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver. Sakurada, K., Uchida, K., Yamaguchi, K., Aisaka, K., Ito, S., Ohmori, T., Takeyama, Y., Ueda, T., Hori, Y., Ohyanagi, H. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  5. Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis. Khvotchev, M.V., Ren, M., Takamori, S., Jahn, R., Südhof, T.C. J. Neurosci. (2003) [Pubmed]
  6. Ethanol-induced alterations in Rab proteins: possible implications for pituitary dysfunction. Ren, J.C., Zhu, Q., Lapaglia, N., Emanuele, N.V., Emanuele, M.A. Alcohol (2005) [Pubmed]
  7. Rab11 is associated with GLUT4-containing vesicles and redistributes in response to insulin. Kessler, A., Tomas, E., Immler, D., Meyer, H.E., Zorzano, A., Eckel, J. Diabetologia (2000) [Pubmed]
  8. Short-term stretch translocates the alpha-1-subunit of the Na pump to plasma membrane. Sevieux, N., Ark, M., Hornick, C., Songu-Mize, E. Cell Biochem. Biophys. (2003) [Pubmed]
  9. Identification and characterization of a novel variant in the highly conserved catalytic center of Rab11a. Uhlig, M., Passlack, W., Eckel, J. European journal of medical genetics. (2006) [Pubmed]
  10. Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor. Volpicelli, L.A., Lah, J.J., Fang, G., Goldenring, J.R., Levey, A.I. J. Neurosci. (2002) [Pubmed]
  11. A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways. Chambers, K., Judson, B., Brown, W.J. J. Cell. Sci. (2005) [Pubmed]
  12. Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct. Barile, M., Pisitkun, T., Yu, M.J., Chou, C.L., Verbalis, M.J., Shen, R.F., Knepper, M.A. Mol. Cell Proteomics (2005) [Pubmed]
  13. The minor regulated pathway, a rapid component of salivary secretion, may provide docking/fusion sites for granule exocytosis at the apical surface of acinar cells. Castle, A.M., Huang, A.Y., Castle, J.D. J. Cell. Sci. (2002) [Pubmed]
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