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Gene Review:

Asic2 - acid-sensing (proton-gated) ion channel 2

Rattus norvegicus

Synonyms: ASIC2, Accn1, Acid-sensing ion channel 2, Amiloride-sensitive brain sodium channel, Amiloride-sensitive brain sodium channel 2, ...

Lingueglia, E. et al., Ugawa, S. et al., Bassilana, F. et al.

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High impact information on Accn1

However, it can associate both with MDEG1 and another recently cloned H+-activated channel DRASIC to form heteropolymers which display different kinetics, pH dependences, and ion selectivities [1].
We have now identified MDEG1 as a proton-gated channel with properties different from those of ASIC [1].
This new membrane protein, which has been called MDEG2, is expressed in both brain and sensory neurons [1].
MDEG1 requires more acidic pH values for activation and has slower inactivation kinetics [1].
A single amino acid substitution in MDEG2 specifically alters desensitization of the proton-activated cation current [2].

Anatomical context of Accn1

Expression of MDEG1 in Xenopus oocytes elicited proton-activated cation currents that were rapidly desensitized [2].

Other interactions of Accn1

Of particular interest is the subunit combination specific for sensory neurons, MDEG2/DRASIC [1].

Analytical, diagnostic and therapeutic context of Accn1

Immunoprecipitation of MDEG causes coprecipitation of ASIC [3].

References

A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. Lingueglia, E., de Weille, J.R., Bassilana, F., Heurteaux, C., Sakai, H., Waldmann, R., Lazdunski, M. J. Biol. Chem. (1997) [Pubmed]
A single amino acid substitution in MDEG2 specifically alters desensitization of the proton-activated cation current. Ugawa, S., Ueda, T., Minami, Y., Horimoto, M., Shimada, S. Neuroreport (2001) [Pubmed]
The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. Bassilana, F., Champigny, G., Waldmann, R., de Weille, J.R., Heurteaux, C., Lazdunski, M. J. Biol. Chem. (1997) [Pubmed]

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