Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ssp1 - serine/threonine protein kinase Ssp1

Schizosaccharomyces pombe 972h-

Rupes, I. et al., Matsusaka, T. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ssp1

Nucleotide sequence determination showed that ssp1+ encodes a novel protein kinase [1].
The ssp1 gene encodes a protein kinase involved in alteration of cell polarity in Schizosaccharomyces pombe. ssp1 deletion causes stress sensitivity, reminiscent of defects in the stress-activated MAP kinase, Spc1; however, the two protein kinases do not act through the same pathway [2].
The ssp1 deletion mutant exhibited monopolar actin distribution, but new end take-off (NETO) could be induced in these cells by exposure to KCl or to latrunculin A pulse treatment [2].

Analytical, diagnostic and therapeutic context of ssp1

Complementation tests showed that suppression was due to two chromosomal loci, ssp1 and ssp2 [1].

References

A novel protein kinase gene ssp1+ is required for alteration of growth polarity and actin localization in fission yeast. Matsusaka, T., Hirata, D., Yanagida, M., Toda, T. EMBO J. (1995) [Pubmed]
Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast. Rupes, I., Jia, Z., Young, P.G. Mol. Biol. Cell (1999) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.