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Chemical Compound Review

AC1NUR4L     (4S)-4- [(1R,4S,5E,7E,11E,15R,17R)- 17...

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Disease relevance of latrunculin a


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Chemical compound and disease context of latrunculin a


Biological context of latrunculin a


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Gene context of latrunculin a


Analytical, diagnostic and therapeutic context of latrunculin a

  • METHODS: Latrunculin-A dose-time-response relationships in BAECs were determined by immunofluorescence and phase contrast light microscopy, facility by two-level constant pressure anterior chamber perfusion [34].
  • We first compared the effects of two actin-disrupting reagents, latrunculin A and cytochalasin D, on the organization of the actin filaments as well as on the insulin action on glucose transport by laser confocal microscopy combined with biochemical analysis of the insulin action [35].
  • Intrahippocampal latrunculin A microdialysis induced seizures during the second and third day of perfusion, and the animals started showing spontaneous seizures 1 month after lartrunculin A administration [36].
  • Pretreatment with cytochalasin D (5 microM) or latrunculin A (3 microM) abolished constriction but enhanced the [Ca(2+)](i) response; similarly, acute application of cytochalasin D to vessels with tone, or in the presence of 60 mM K(+), elicited relaxation accompanied by an increase in [Ca(2+)](i) [37].
  • Latrunculin A was evaluated in an sc-implanted human A549 lung tumor xenograft mouse model and yielded a T/C of 146% [38].


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  20. Dissecting docking and tethering of secretory vesicles at the target membrane. Toonen, R.F., Kochubey, O., de Wit, H., Gulyas-Kovacs, A., Konijnenburg, B., Sørensen, J.B., Klingauf, J., Verhage, M. EMBO J. (2006) [Pubmed]
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  33. An interaction between Sla1p and Sla2p plays a role in regulating actin dynamics and endocytosis in budding yeast. Gourlay, C.W., Dewar, H., Warren, D.T., Costa, R., Satish, N., Ayscough, K.R. J. Cell. Sci. (2003) [Pubmed]
  34. Latrunculin-A increases outflow facility in the monkey. Peterson, J.A., Tian, B., Bershadsky, A.D., Volberg, T., Gangnon, R.E., Spector, I., Geiger, B., Kaufman, P.L. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
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