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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

rae1  -  RNA export factor, nucleoporin Rae1

Schizosaccharomyces pombe 972h-

 
 
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High impact information on rae1

  • We have used synthetic lethal genetic screens in Schizosaccharomyces pombe to identify mutations in genes that are functionally linked to rae1 and mex67 in mRNA export [1].
  • A mutation in the Schizosaccharomyces pombe rae1 gene causes defects in poly(A)+ RNA export and in the cytoskeleton [2].
  • Results from experiments in which rae1-1 cells were arrested in various phases of the cell division cycle and then shifted to nonpermissive temperature suggest that cells are particularly vulnerable to loss of rae1 function during G2/M [2].
  • Advancement through mitosis requires rae1 gene function in fission yeast [3].
  • We propose a model where rae1 functions in cell cycle progression through trafficking of proteins required for mitosis [3].
 

Biological context of rae1

  • We demonstrate here that rae1 function is required for a process other than mRNA export which is essential for advancement through mitosis [3].

References

  1. Elf1p, a member of the ABC class of ATPases, functions as a mRNA export factor in Schizosacchromyces pombe. Kozak, L., Gopal, G., Yoon, J.H., Sauna, Z.E., Ambudkar, S.V., Thakurta, A.G., Dhar, R. J. Biol. Chem. (2002) [Pubmed]
  2. A mutation in the Schizosaccharomyces pombe rae1 gene causes defects in poly(A)+ RNA export and in the cytoskeleton. Brown, J.A., Bharathi, A., Ghosh, A., Whalen, W., Fitzgerald, E., Dhar, R. J. Biol. Chem. (1995) [Pubmed]
  3. Advancement through mitosis requires rae1 gene function in fission yeast. Whalen, W.A., Bharathi, A., Danielewicz, D., Dhar, R. Yeast (1997) [Pubmed]
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