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Gene Review

RAE1  -  ribonucleic acid export 1

Homo sapiens

Synonyms: MIG14, MRNP41, Mnrp41, Rae1 protein homolog, dJ481F12.3, ...
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Disease relevance of RAE1


High impact information on RAE1

  • A purified Rae1 complex stabilizes microtubules in egg extracts in a RanGTP/importin beta-regulated manner [3].
  • RAE-1 proteins (alpha, beta, gamma, and delta) are distant major histocompatibility complex (MHC) class I homologs, comprising isolated alpha1alpha2 platform domains [4].
  • The up-regulation of RAE-1 by E1A targeted MCA-205 tumor cells to lysis by NK cells, resulting in NKG2D-dependent tumor rejection in vivo [5].
  • Together, our data suggest that RAE1 is a shuttling transport factor that directly contributes to nuclear export of mRNAs through its ability to anchor to a specific NUP98 motif at the NPC [6].
  • RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains [6].

Biological context of RAE1


Anatomical context of RAE1


Associations of RAE1 with chemical compounds


Other interactions of RAE1

  • The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins [7].
  • Since Nup98 and Rae1p/Gle2p have been reported to be involved in mRNA export, this suggests that some of the mitotic subcomplex may be formed by functionally related proteins [13].
  • Natural killer (NK) cell function is regulated by NK receptors that bind either classical MHC class I (MHC-I) molecules or their structural relatives (MICA, RAE-1 and H-60) [14].

Analytical, diagnostic and therapeutic context of RAE1

  • Immunofluorescence microscopy localized mrnp 41 to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm [8].
  • Western blotting and immunohistochemical assays showed that there was absent or faint H60 and RAE-1 expression in sham liver, but they were apparently increased in ischemic liver; however, the expressions were significantly decreased in the presence of YS [2].


  1. Viral interactions with the nuclear transport machinery: discovering and disrupting pathways. Fontoura, B.M., Faria, P.A., Nussenzveig, D.R. IUBMB Life (2005) [Pubmed]
  2. Yisheng Injection Decreases the Expression of H60 and RAE-1 Genes in Ischemic Mice Liver. Cheng, F., Feng, L., Li, S., Tan, J., Cao, L., He, Y., Ye, Z., Li, Y. Transplant. Proc. (2006) [Pubmed]
  3. A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Blower, M.D., Nachury, M., Heald, R., Weis, K. Cell (2005) [Pubmed]
  4. Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D. Li, P., McDermott, G., Strong, R.K. Immunity (2002) [Pubmed]
  5. Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection. Routes, J.M., Ryan, S., Morris, K., Takaki, R., Cerwenka, A., Lanier, L.L. J. Exp. Med. (2005) [Pubmed]
  6. RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains. Pritchard, C.E., Fornerod, M., Kasper, L.H., van Deursen, J.M. J. Cell Biol. (1999) [Pubmed]
  7. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. Wang, X., Babu, J.R., Harden, J.M., Jablonski, S.A., Gazi, M.H., Lingle, W.L., de Groen, P.C., Yen, T.J., van Deursen, J.M. J. Biol. Chem. (2001) [Pubmed]
  8. mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm. Kraemer, D., Blobel, G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Mrnp41 (Rae 1p) associates with microtubules in HeLa cells and in neurons. Kraemer, D., Dresbach, T., Drenckhahn, D. Eur. J. Cell Biol. (2001) [Pubmed]
  10. Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. Nomura, M., Zou, Z., Joh, T., Takihara, Y., Matsuda, Y., Shimada, K. J. Biochem. (1996) [Pubmed]
  11. Differential mitotic checkpoint protein requirements in somatic and germ cells. Jeganathan, K.B., van Deursen, J.M. Biochem. Soc. Trans. (2006) [Pubmed]
  12. The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of Poly(A)+ RNA. Bharathi, A., Ghosh, A., Whalen, W.A., Yoon, J.H., Pu, R., Dasso, M., Dhar, R. Gene (1997) [Pubmed]
  13. Identification and characterization of nuclear pore subcomplexes in mitotic extract of human somatic cells. Matsuoka, Y., Takagi, M., Ban, T., Miyazaki, M., Yamamoto, T., Kondo, Y., Yoneda, Y. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  14. MHC class I recognition by Ly49 natural killer cell receptors. Natarajan, K., Dimasi, N., Wang, J., Margulies, D.H., Mariuzza, R.A. Mol. Immunol. (2002) [Pubmed]
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