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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Terms

 

Gene Review: 

Rae1  -  RAE1 RNA export 1 homolog (S. pombe)

Mus musculus

Synonyms: 3230401I12Rik, 41, D2Ertd342e, MNRP, MNRP41, ...
 
 
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Disease relevance of Rae1

 

High impact information on Rae1

  • Mice that are exposed to live or irradiated tumour cells expressing Rae1 or H60 are specifically immune to subsequent challenge with tumour cells that lack NKG2D ligands, suggesting application of the ligands in the design of tumour vaccines [2].
  • VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway [3].
  • Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice [4].
  • Tumors growing in the presence of any of these components also show reduced expression of Rae-1, a ligand for the activating NK receptor, NKG2D [5].
  • Disruption of Mad2, BubR1, Bub3 or Rae1 in mice results in substantial aneuploidy in somatic tissues, but whether these genes are equally important for accurate chromosome segregation during meiosis has not yet been established [6].
 

Biological context of Rae1

  • The nuclear transport factors Rae1 and Nup98, which convert into mitotic checkpoint proteins in M-phase, further prevent chromosome missegregation by assembling into a complex with APC(Cdh1) and delaying APC(Cdh1)-mediated ubiquitination of securin [6].
  • Furthermore, although BubR1 hypomorphic mice have less aneuploidy than Bub3/Rae1 haploinsufficient mice, they age much faster [4].
  • Dissociation of Rae1 and Nup98 from APC(Cdh1) coincides with the release of the mitotic checkpoint protein BubR1 from Cdc20-activated APC (APC(Cdc20)) at the metaphase to anaphase transition [7].
  • Here we show that in mitosis timely destruction of securin by APC is regulated by the nucleocytoplasmic transport factors Rae1 and Nup98 [7].
  • Here we show that Rae1 and Nup98 not only form a complex with APC(Cdh1) in prometaphase but also with securin [8].
 

Other interactions of Rae1

  • We further report here that mutant mice with low levels of the Rae1-Nup98 complex are not prone to develop spontaneous tumors, despite massive aneuploidy [8].
  • We propose that the formation of APC(Cdh1)-securin complexes in prometaphase primes the cell for rapid securin degradation after release of the inhibitory Rae1-Nup98 complex at the metaphase/anaphase transition [8].

References

  1. Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: a novel cDNA family encodes cell surface proteins sharing partial homology with MHC class I molecules. Zou, Z., Nomura, M., Takihara, Y., Yasunaga, T., Shimada, K. J. Biochem. (1996) [Pubmed]
  2. Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Diefenbach, A., Jensen, E.R., Jamieson, A.M., Raulet, D.H. Nature (2001) [Pubmed]
  3. VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway. Faria, P.A., Chakraborty, P., Levay, A., Barber, G.N., Ezelle, H.J., Enninga, J., Arana, C., van Deursen, J., Fontoura, B.M. Mol. Cell (2005) [Pubmed]
  4. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. Baker, D.J., Jeganathan, K.B., Malureanu, L., Perez-Terzic, C., Terzic, A., van Deursen, J.M. J. Cell Biol. (2006) [Pubmed]
  5. Characterizing the protective component of the alphabeta T cell response to transplantable squamous cell carcinoma. Girardi, M., Oppenheim, D., Glusac, E.J., Filler, R., Balmain, A., Tigelaar, R.E., Hayday, A.C. J. Invest. Dermatol. (2004) [Pubmed]
  6. Differential mitotic checkpoint protein requirements in somatic and germ cells. Jeganathan, K.B., van Deursen, J.M. Biochem. Soc. Trans. (2006) [Pubmed]
  7. The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Jeganathan, K.B., Malureanu, L., van Deursen, J.M. Nature (2005) [Pubmed]
  8. Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Jeganathan, K.B., Baker, D.J., van Deursen, J.M. Cell Cycle (2006) [Pubmed]
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