High impact information on dsk1

• Furthermore, dsk1(+) gene determines the phenotype of prp2(+) overexpression, providing in vivo evidence that Prp2 is a target for Dsk1 [1].
• A mitotic role for a novel fission yeast protein kinase dsk1 with cell cycle stage dependent phosphorylation and localization [2].
• Immunofluorescence microscopy using anti-dsk1 antibody shows that localization pattern of dsk1 protein strikingly alters depending on cell cycle stages [2].
• We discuss possible roles of dsk1 kinase as an add-on regulator in mitosis [2].
• The haploid gene disruptant is viable, indicating that the dsk1+ gene is non-essential for viability [2].

Biological context of dsk1

• Hence dsk1 protein may play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity [2].
• A multicopy suppressor gene for hos- mutations was also isolated and identified as the dsk1+ gene encoding a protein kinase, which was previously suggested to be implicated in a process of the mitotic regulation of S. pombe [3].

References