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Gene Review

cdk9  -  P-TEFb-associated cyclin-dependent protein...

Schizosaccharomyces pombe 972h-

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High impact information on SPBC32H8.10

  • Among 11 coding sequences (CDSs) predicted by the gene finding software INTRON.PLOT., four CDSs, pi007, pi010, pi014 and pi016, had considerable similarity to 40S ribosomal protein, glycosyltransferase, cdc2-related protein kinase and alpha-1, 2-mannosyltransferase, respectively [1].
  • BACKGROUND: The p13suc1 gene product is a member of the cks (cyclin-dependent protein kinase subunit) protein family and has been implicated in regulation of the cell cycle [2].

Analytical, diagnostic and therapeutic context of SPBC32H8.10

  • Site-directed mutagenesis was used to show that a sequence that matches the zRxL motif found in mammalian CDK inhibitors is essential for Sicl function [3].


  1. A 38 kb segment containing the cdc2 gene from the left arm of fission yeast chromosome II: sequence analysis and characterization of the genomic DNA and cDNAs encoded on the segment. Machida, M., Yamazaki, S., Kunihiro, S., Tanaka, T., Kushida, N., Jinnno, K., Haikawa, Y., Yamazaki, J., Yamamoto, S., Sekine, M., Oguchi, A., Nagai, Y., Sakai, M., Aoki, K., Ogura, K., Kudoh, Y., Kikuchi, H., Zhang, M.Q., Yanagida, M. Yeast (2000) [Pubmed]
  2. Characterization of the unfolding pathway of the cell-cycle protein p13suc1 by molecular dynamics simulations: implications for domain swapping. Alonso, D.O., Alm, E., Daggett, V. Structure (2000) [Pubmed]
  3. The cyclin-dependent kinase inhibitory domain of the yeast Sic1 protein is contained within the C-terminal 70 amino acids. Hodge, A., Mendenhall, M. Mol. Gen. Genet. (1999) [Pubmed]
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