The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Cdk9  -  Cyclin-dependent kinase 9

Drosophila melanogaster

Synonyms: CDK9, CG5179, Dmel\CG5179, P-TEF, P-TEFb, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Cdk9

  • Our results suggest that P-TEFb represents an attractive target for the development of novel HIV therapeutics [1].
 

High impact information on Cdk9

 

Biological context of Cdk9

 

Associations of Cdk9 with chemical compounds

 

Other interactions of Cdk9

  • Like other CDKs, CDK9 is essentially inactive in the absence of its cyclin partner [6].

References

  1. P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Mancebo, H.S., Lee, G., Flygare, J., Tomassini, J., Luu, P., Zhu, Y., Peng, J., Blau, C., Hazuda, D., Price, D., Flores, O. Genes Dev. (1997) [Pubmed]
  2. P-TEFb kinase recruitment and function at heat shock loci. Lis, J.T., Mason, P., Peng, J., Price, D.H., Werner, J. Genes Dev. (2000) [Pubmed]
  3. Identification of multiple cyclin subunits of human P-TEFb. Peng, J., Zhu, Y., Milton, J.T., Price, D.H. Genes Dev. (1998) [Pubmed]
  4. Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes. Ni, Z., Schwartz, B.E., Werner, J., Suarez, J.R., Lis, J.T. Mol. Cell (2004) [Pubmed]
  5. Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Eissenberg, J.C., Shilatifard, A., Dorokhov, N., Michener, D.E. Mol. Genet. Genomics (2007) [Pubmed]
  6. Identification of a cyclin subunit required for the function of Drosophila P-TEFb. Peng, J., Marshall, N.F., Price, D.H. J. Biol. Chem. (1998) [Pubmed]
  7. Control of formation of two distinct classes of RNA polymerase II elongation complexes. Marshall, N.F., Price, D.H. Mol. Cell. Biol. (1992) [Pubmed]
  8. Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. Chao, S.H., Price, D.H. J. Biol. Chem. (2001) [Pubmed]
 
WikiGenes - Universities