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Gene Review

Cdk9  -  Cyclin-dependent kinase 9

Drosophila melanogaster

Synonyms: CDK9, CG5179, Dmel\CG5179, P-TEF, P-TEFb, ...
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Disease relevance of Cdk9

  • Our results suggest that P-TEFb represents an attractive target for the development of novel HIV therapeutics [1].

High impact information on Cdk9


Biological context of Cdk9


Associations of Cdk9 with chemical compounds


Other interactions of Cdk9

  • Like other CDKs, CDK9 is essentially inactive in the absence of its cyclin partner [6].


  1. P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Mancebo, H.S., Lee, G., Flygare, J., Tomassini, J., Luu, P., Zhu, Y., Peng, J., Blau, C., Hazuda, D., Price, D., Flores, O. Genes Dev. (1997) [Pubmed]
  2. P-TEFb kinase recruitment and function at heat shock loci. Lis, J.T., Mason, P., Peng, J., Price, D.H., Werner, J. Genes Dev. (2000) [Pubmed]
  3. Identification of multiple cyclin subunits of human P-TEFb. Peng, J., Zhu, Y., Milton, J.T., Price, D.H. Genes Dev. (1998) [Pubmed]
  4. Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes. Ni, Z., Schwartz, B.E., Werner, J., Suarez, J.R., Lis, J.T. Mol. Cell (2004) [Pubmed]
  5. Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Eissenberg, J.C., Shilatifard, A., Dorokhov, N., Michener, D.E. Mol. Genet. Genomics (2007) [Pubmed]
  6. Identification of a cyclin subunit required for the function of Drosophila P-TEFb. Peng, J., Marshall, N.F., Price, D.H. J. Biol. Chem. (1998) [Pubmed]
  7. Control of formation of two distinct classes of RNA polymerase II elongation complexes. Marshall, N.F., Price, D.H. Mol. Cell. Biol. (1992) [Pubmed]
  8. Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. Chao, S.H., Price, D.H. J. Biol. Chem. (2001) [Pubmed]
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