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Gene Review:

eri1 - double-strand siRNA ribonuclease Eri1

Schizosaccharomyces pombe 972h-

Käslin, E. et al., Szankasi, P. et al., Feng, W. et al., Mansour, A.A. et al.

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High impact information on SPBC30B4.08

Here we demonstrate that the N-terminal half of Pol epsilon that includes the highly conserved polymerase and exonuclease domains is dispensable for cell viability, similar to observations made with regard to Saccharomyces cerevisiae [1].
A DNA exonuclease induced during meiosis of Schizosaccharomyces pombe [2].
In meiotic cells of the fission yeast Schizosaccharomyces pombe, a DNA exonuclease activity increased approximately 5-fold after premeiotic S-phase and decreased to the initial level before the meiotic divisions [2].
Also inactivation of exo1, which encodes an exonuclease that has an MMR-dependent function in repair of base-base mismatches, caused only slightly increased repeat instability [3].

Analytical, diagnostic and therapeutic context of SPBC30B4.08

Direct comparison of the biochemical properties, sequence analysis, and cross-reactivity to a monoclonal antibody suggests that p140 is probably identical with ExoII, purified from S. pombe meiotic cells as a ssDNA exonuclease (Szankasi, P., and Smith, G. R. (1992) Biochemistry 31, 6769-6773) [4].

References

Schizosaccharomyces pombe cells lacking the amino-terminal catalytic domains of DNA polymerase epsilon are viable but require the DNA damage checkpoint control. Feng, W., D'Urso, G. Mol. Cell. Biol. (2001) [Pubmed]
A DNA exonuclease induced during meiosis of Schizosaccharomyces pombe. Szankasi, P., Smith, G.R. J. Biol. Chem. (1992) [Pubmed]
Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors. Mansour, A.A., Tornier, C., Lehmann, E., Darmon, M., Fleck, O. Genetics (2001) [Pubmed]
A multifunctional exonuclease from vegetative Schizosaccharomyces pombe cells exhibiting in vitro strand exchange activity. Käslin, E., Heyer, W.D. J. Biol. Chem. (1994) [Pubmed]

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ERI1	Bos taurus
eri-1	Caenorhabditis elegans
ERI1	Canis lupus familiaris
eri1	Danio rerio
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LOC699381	Macaca mulatta
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eri1	Xenopus (Silurana) tropicalis

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