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suc22  -  ribonucleotide reductase small subunit Suc22

Schizosaccharomyces pombe 972h-

 
 
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High impact information on suc22

  • Unlike conventional poly(A) polymerases, which act in the nucleus and indiscriminately polyadenylate all mRNA, Cid13 is a cytoplasmic enzyme that specifically targets suc22 mRNA that encodes a subunit of ribonucleotide reductase (RNR). cid13 mutants have reduced dNTP pools and are sensitive to hydroxyurea, an RNR inhibitor [1].
  • The sequences of the cdc22+ gene and of a multicopy suppressor of cdc22ts mutations, suc22+, have been determined [2].
  • The cell cycle genes cdc22+ and suc22+ of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase [2].
  • The suc22+ gene contains an uninterrupted open reading frame of 391 amino acids, very similar to the sequence of the small subunit of ribonucleotide reductase [2].

References

  1. Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Saitoh, S., Chabes, A., McDonald, W.H., Thelander, L., Yates, J.R., Russell, P. Cell (2002) [Pubmed]
  2. The cell cycle genes cdc22+ and suc22+ of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase. Fernandez Sarabia, M.J., McInerny, C., Harris, P., Gordon, C., Fantes, P. Mol. Gen. Genet. (1993) [Pubmed]
 
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