Gene Review:
RRM2 - ribonucleotide reductase M2
Homo sapiens
Synonyms:
R2, RR2, RR2M, Ribonucleoside-diphosphate reductase subunit M2, Ribonucleotide reductase small chain, ...
- RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine. Duxbury, M.S., Ito, H., Zinner, M.J., Ashley, S.W., Whang, E.E. Oncogene (2004)
- Amplification of N-myc and ornithine decarboxylase genes in human neuroblastoma and hydroxyurea-resistant hamster cell lines. Tonin, P.N., Yeger, H., Stallings, R.L., Srinivasan, P.R., Lewis, W.H. Oncogene (1989)
- Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors. Lin, Z.P., Belcourt, M.F., Cory, J.G., Sartorelli, A.C. J. Biol. Chem. (2004)
- Development of resistance to hydroxyurea during treatment of human myelogenous leukemia K562 cells with alpha-difluoromethylornithine as a result of coamplification of genes for ornithine decarboxylase and ribonucleotide reductase R2 subunit. Ask, A., Persson, L., Rehnholm, A., Frostesjö, L., Holm, I., Heby, O. Cancer Res. (1993)
- Modeling of photodecoloration of azo dye in a cocktail photolysis system. Chu, W., Tsui, S.M. Water Res. (2002)
- A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Tanaka, H., Arakawa, H., Yamaguchi, T., Shiraishi, K., Fukuda, S., Matsui, K., Takei, Y., Nakamura, Y. Nature (2000)
- Unusual clustering of carboxyl side chains in the core of iron-free ribonucleotide reductase. Aberg, A., Nordlund, P., Eklund, H. Nature (1993)
- Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. Cáceres, J.F., Misteli, T., Screaton, G.R., Spector, D.L., Krainer, A.R. J. Cell Biol. (1997)
- Analysis of ribonucleotide reductase M2 mRNA levels in patient samples after GTI-2040 antisense drug treatment. Juhasz, A., Vassilakos, A., Chew, H.K., Gandara, D., Yen, Y. Oncol. Rep. (2006)
- Tumor necrosis factor alpha and its receptors in relapsing-remitting multiple sclerosis. Martino, G., Consiglio, A., Franciotta, D.M., Corti, A., Filippi, M., Vandenbroeck, K., Sciacca, F.L., Comi, G., Grimaldi, L.M. J. Neurol. Sci. (1997)
- Spectroscopic and computational studies of the de novo designed protein DF2t: correlation to the biferrous active site of ribonucleotide reductase and factors that affect O2 reactivity. Wei, P.P., Skulan, A.J., Wade, H., DeGrado, W.F., Solomon, E.I. J. Am. Chem. Soc. (2005)
- Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training. Blüher, M., Bullen, J.W., Lee, J.H., Kralisch, S., Fasshauer, M., Klöting, N., Niebauer, J., Schön, M.R., Williams, C.J., Mantzoros, C.S. J. Clin. Endocrinol. Metab. (2006)
- A phase I study of antisense oligonucleotide GTI-2040 given by continuous intravenous infusion in patients with advanced solid tumors. Desai, A.A., Schilsky, R.L., Young, A., Janisch, L., Stadler, W.M., Vogelzang, N.J., Cadden, S., Wright, J.A., Ratain, M.J. Ann. Oncol. (2005)
- Suppression of lung tumor formation by the regulatory subunit of ribonucleotide reductase. Gautam, A., Bepler, G. Cancer Res. (2006)
- Contributions of the individual domains in human La protein to its RNA 3'-end binding activity. Ohndorf, U.M., Steegborn, C., Knijff, R., Sondermann, P. J. Biol. Chem. (2001)
- Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing. Mehta, A., Driscoll, D.M. RNA (2002)
- Ribonucleotide reductase M2 subunit sequences mapped to four different chromosomal sites in humans and mice: functional locus identified by its amplification in hydroxyurea-resistant cell lines. Yang-Feng, T.L., Barton, D.E., Thelander, L., Lewis, W.H., Srinivasan, P.R., Francke, U. Genomics (1987)
- An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines. Davidson, J.D., Ma, L., Flagella, M., Geeganage, S., Gelbert, L.M., Slapak, C.A. Cancer Res. (2004)
- The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53. Zhou, B., Liu, X., Mo, X., Xue, L., Darwish, D., Qiu, W., Shih, J., Hwu, E.B., Luh, F., Yen, Y. Cancer Res. (2003)
- La protein binding at the GCAC site near the initiator AUG facilitates the ribosomal assembly on the hepatitis C virus RNA to influence internal ribosome entry site-mediated translation. Pudi, R., Srinivasan, P., Das, S. J. Biol. Chem. (2004)
- An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles. Dye, B.T., Patton, J.G. Exp. Cell Res. (2001)
- In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase. Shao, J., Zhou, B., Zhu, L., Qiu, W., Yuan, Y.C., Xi, B., Yen, Y. Cancer Res. (2004)
- Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis. Kash, J.C., Cunningham, D.M., Smit, M.W., Park, Y., Fritz, D., Wilusz, J., Katze, M.G. J. Virol. (2002)
- Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process. Yee, C.S., Seyedsayamdost, M.R., Chang, M.C., Nocera, D.G., Stubbe, J. Biochemistry (2003)
- A rice homolog of Cdk7/MO15 phosphorylates both cyclin-dependent protein kinases and the carboxy-terminal domain of RNA polymerase II. Yamaguchi, M., Umeda, M., Uchimiya, H. Plant J. (1998)
- The novel protein kinase of the RR1 subunit of herpes simplex virus has autophosphorylation and transphosphorylation activity that differs in its ATP requirements for HSV-1 and HSV-2. Peng, T., Hunter, J.R., Nelson, J.W. Virology (1996)
- Activation of CDK-activating kinase is dependent on interaction with H-type cyclins in plants. Yamaguchi, M., Fabian, T., Sauter, M., Bhalerao, R.P., Schrader, J., Sandberg, G., Umeda, M., Uchimiya, H. Plant J. (2000)
- Resistance of herpes simplex virus type 1 to peptidomimetic ribonucleotide reductase inhibitors: selection and characterization of mutant isolates. Bonneau, A.M., Kibler, P., White, P., Bousquet, C., Dansereau, N., Cordingley, M.G. J. Virol. (1996)
- RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer. Bepler, G., Sharma, S., Cantor, A., Gautam, A., Haura, E., Simon, G., Sharma, A., Sommers, E., Robinson, L. J. Clin. Oncol. (2004)
- Novel DNA-binding properties of the RNA-binding protein TIAR. Suswam, E.A., Li, Y.Y., Mahtani, H., King, P.H. Nucleic Acids Res. (2005)
- Increased Expression of Thymidylate Synthetase (TS), Ubiquitin Specific Protease 10 (USP10) and Survivin is Associated with Poor Survival in Glioblastoma Multiforme (GBM). Grunda, J.M., Nabors, L.B., Palmer, C.A., Chhieng, D.C., Steg, A., Mikkelsen, T., Diasio, R.B., Zhang, K., Allison, D., Grizzle, W.E., Wang, W., Gillespie, G.Y., Johnson, M.R. J. Neurooncol. (2006)
- Human ribonucleotide reductase M2 subunit gene amplification and transcriptional regulation in a homogeneous staining chromosome region responsible for the mechanism of drug resistance. Zhou, B., Mo, X., Liu, X., Qiu, W., Yen, Y. Cytogenet. Cell Genet. (2001)