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Gene Review

cdc22  -  ribonucleoside reductase large subunit Cdc22

Schizosaccharomyces pombe 972h-

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High impact information on cdc22

  • Following S-phase stall induced by hydroxyurea or a cdc22 mutation, the chromatin-bound Rad17 progressively dissociates from the chromatin [1].
  • The sequences of the cdc22+ gene and of a multicopy suppressor of cdc22ts mutations, suc22+, have been determined [2].
  • Inhibition of DNA synthesis by hydroxyurea results in a several-fold increase in the level of the cdc22+ transcript [2].
  • The cdc22+ gene of Schizosaccharomyces pombe is required early in the cell cycle, and its transcript varies in concentration in step with the cell cycle, with a peak level at the G1-S boundary [2].
  • The cdc22+ open reading frame, which is interrupted in the genome by a single intron very close to its 5' end, encodes a protein of 811 amino acids, which has an amino acid sequence highly similar to that of the large subunit of ribonucleotide reductase from several species [2].

Biological context of cdc22

  • The effect of mutating and over-expressing individual components of DSC1 (cdc10+, res1+, res2+, rep1+ and rep2+) on the transcription of cdc22+, rec8+ and rec11+ during meiosis was examined [3].
  • Several genes, including rec8+, rec11+, cdc18+, and cdc22+, which contain MCB motifs in their promoter regions, are found to be co-ordinately regulated during pre-meiotic S-phase [3].

Analytical, diagnostic and therapeutic context of cdc22

  • We determined that p72res1 can bind specifically to the cdc22 promoter, when analyzed by gel mobility shift assay, and that the N-terminal 157 amino acids of p72res1 are sufficient for this specific binding [4].
  • Sequence analysis of the pol alpha+ and pol delta+ genes did not reveal the Mlu I motifs in their upstream sequences that are involved in cell cycle-dependent transcription of S. cerevisiae DNA synthesis genes as well as the S. pombe cdc22+ gene at the G1/S boundary [5].


  1. Fission yeast Rad17 associates with chromatin in response to aberrant genomic structures. Kai, M., Tanaka, H., Wang, T.S. Mol. Cell. Biol. (2001) [Pubmed]
  2. The cell cycle genes cdc22+ and suc22+ of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase. Fernandez Sarabia, M.J., McInerny, C., Harris, P., Gordon, C., Fantes, P. Mol. Gen. Genet. (1993) [Pubmed]
  3. DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe. Cunliffe, L., White, S., McInerny, C.J. Mol. Genet. Genomics (2004) [Pubmed]
  4. The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase. Ayté, J., Leis, J.F., Herrera, A., Tang, E., Yang, H., DeCaprio, J.A. Mol. Cell. Biol. (1995) [Pubmed]
  5. Cell cycle expression of two replicative DNA polymerases alpha and delta from Schizosaccharomyces pombe. Park, H., Francesconi, S., Wang, T.S. Mol. Biol. Cell (1993) [Pubmed]
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