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Gene Review:

pho4 - thiamine-repressible acid phosphatase Pho4

Schizosaccharomyces pombe 972h-

Yang, J.W. et al., Schweingruber, A.M. et al., Silvestre, N. et al., Schweingruber, A.M. et al.

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High impact information on pho4

Mutants expressing repressed levels of thiamine-repressible acid phosphatase map in gene thi1 [1].
The organisation of the pho4 promoter is remarkable in that UAS and TATA box are very closely associated [2].
We have investigated the thiamine metabolism in Schizosaccharomyces pombe and shown that: (1) Thiamine-repressible acid phosphate, coded for by the gene pho4, dephosphorylates thiamine phosphates indicating that the enzyme acts as a thiamine phosphate phosphatase [3].
The nucleotide sequence of this gene is given here and it is shown that it matches the amino acid sequence of thiamin-repressible acid phosphatase, corroborating genetic evidence that pho4 represents the structural gene of this enzyme [4].

Associations of pho4 with chemical compounds

The pho4 gene of the fission yeast Schizosaccharomyces pombe is regulated by thiamin [4].

References

Isolation and characterization of regulatory mutants from Schizosaccharomyces pombe involved in thiamine-regulated gene expression. Schweingruber, A.M., Fankhauser, H., Dlugonski, J., Steinmann-Loss, C., Schweingruber, M.E. Genetics (1992) [Pubmed]
Characterization of upstream activating sequences involved in activation and regulation of pho4 expression in Schizosaccharomyces pombe. Silvestre, N., Jacobs, E. Mol. Gen. Genet. (1997) [Pubmed]
Thiamine in Schizosaccharomyces pombe: dephosphorylation, intracellular pool, biosynthesis and transport. Schweingruber, A.M., Dlugonski, J., Edenharter, E., Schweingruber, M.E. Curr. Genet. (1991) [Pubmed]
The structural gene coding for thiamin-repressible acid phosphatase in Schizosaccharomyces pombe. Yang, J.W., Schweingruber, M.E. Curr. Genet. (1990) [Pubmed]

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KLLA0C19338g	Kluyveromyces lactis NRRL Y-1140
MGG_09199	Magnaporthe oryzae 70-15
PHO3	Saccharomyces cerevisiae S288c
PHO5	Saccharomyces cerevisiae S288c
PHO11	Saccharomyces cerevisiae S288c
DIA3	Saccharomyces cerevisiae S288c
PHO12	Saccharomyces cerevisiae S288c
pho1	Schizosaccharomyces pombe 972h-
SPBC21H7.03c	Schizosaccharomyces pombe 972h-

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