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Gene Review

PHO11  -  Pho11p

Saccharomyces cerevisiae S288c

Synonyms: Acid phosphatase PHO11, P56, YAR071W
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High impact information on PHO11


Other interactions of PHO11

  • A high correlation coefficient between bud formation and secretion of Pho5p phosphatase and the absence of correlation between bud formation and secretion of minor phosphatases Pho10p and Pho11p suggests different functional roles of the polypeptides that constitute the native repressible acid phosphatase [5].
  • It was shown that the constitutive acid phosphatase (PHO3 gene product) is mainly transported to the cell surface by a lower density population of vesicles, while the repressible acid phosphatase (a heteromer encoded by PHO5, PHO10, and PHO11 genes) by a vesicle population of higher density [5].
  • Crossing these three strains with two other ones having markers for ADE1 and pho11::LEU2, we could map the mutation at ca. 4.3 cM and ca. 37.7 cM from the PHO11 and ADE1 loci respectively [6].

Analytical, diagnostic and therapeutic context of PHO11

  • The values of Mr estimated by HPLC chromatography for the enzymes encoded for by the genes PHO5, PHO10 and PHO11 and SDS-polyacrilamide gel electrophoresis data suggested an oligomeric organisation of the enzymes [7].
  • We have now identified PHO10 and show by restriction mapping that it is highly homologous to PHO11 [2].


  1. Structure of the transcriptionally repressed phosphate-repressible acid phosphatase gene (PHO5) of Saccharomyces cerevisiae. Bergman, L.W., Stranathan, M.C., Preis, L.H. Mol. Cell. Biol. (1986) [Pubmed]
  2. The acid phosphatase genes PHO10 and PHO11 in S. cerevisiae are located at the telomeres of chromosomes VIII and I. Venter, U., Hörz, W. Nucleic Acids Res. (1989) [Pubmed]
  3. Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: characterization of the 54 kb right terminal CDC15-FLO1-PHO11 region. Barton, A.B., Bussey, H., Storms, R.K., Kaback, D.B. Yeast (1997) [Pubmed]
  4. Physical localization of the flocculation gene FLO1 on chromosome I of Saccharomyces cerevisiae. Teunissen, A.W., van den Berg, J.A., Steensma, H.Y. Yeast (1993) [Pubmed]
  5. Vesicular transport of extracellular acid phosphatases in yeast Saccharomyces cerevisiae. Blinnikova, E.I., Mirjuschenko, F.L., Shabalin, Y.A., Egorov, S.N. Biochemistry Mosc. (2002) [Pubmed]
  6. Isolation and characterization of a mutant of Saccharomyces cerevisiae affected in the FLO1 locus. Reboredo, N.M., Sieiro, C., Blanco, P., Villa, T.G. FEMS Microbiol. Lett. (1996) [Pubmed]
  7. Biochemical properties and excretion behavior of repressible acid phosphatases with altered subunit composition. Shnyreva, M.G., Petrova, E.V., Egorov, S.N., Hinnen, A. Microbiol. Res. (1996) [Pubmed]
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