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Gene Review

pho1  -  acid phosphatase Pho1

Schizosaccharomyces pombe 972h-

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High impact information on pho1

  • Pho4 is not genetically linked to the phosphate repressible acid phosphatase gene pho1 [1].
  • In Schizosaccharomyces pombe the 14-3-3 protein Rad24p is involved in negative control of pho1 gene expression [2].
  • Strains carrying mutated structural genes for three different phosphatases, pho1, pho2 or pho3, degraded polyphosphate at the same rate as the wild-type strain during phosphate starvation and showed the same type of over-compensation when phosphate was added again [3].
  • They define four genes (anr1, anr2, anr3, and anr5) which are involved in adenine-dependent pho1 expression [4].

Biological context of pho1


Associations of pho1 with chemical compounds


  1. Identification and characterization of thiamin repressible acid phosphatase in yeast. Schweingruber, M.E., Fluri, R., Maundrell, K., Schweingruber, A.M., Dumermuth, E. J. Biol. Chem. (1986) [Pubmed]
  2. In Schizosaccharomyces pombe the 14-3-3 protein Rad24p is involved in negative control of pho1 gene expression. Voicu, P.M., Petrescu-Danila, E., Poitelea, M., Watson, A.T., Rusu, M. Yeast (2007) [Pubmed]
  3. Synthesis and degradation of polyphosphate in the fission yeast Schizosaccharomyces pombe: mutations in phosphatase genes do not affect polyphosphate metabolism. Müller, J., Westenberg, B., Boller, T., Wiemken, A. FEMS Microbiol. Lett. (1992) [Pubmed]
  4. Regulation of pho1-encoded acid phosphatase of Schizosaccharomyces pombe by adenine and phosphate. Schweingruber, M.E., Edenharter, E., Zurlinden, A., Stockmaier, K.M. Curr. Genet. (1992) [Pubmed]
  5. Effects of seven different mutations in the pho1 gene on enzymatic activity, glycosylation and secretion of acid phosphatase in Schizosaccharomyces pombe. Schwaninger, R., Dumermuth, E., Schweingruber, M.E. Mol. Gen. Genet. (1990) [Pubmed]
  6. Cloning and characterization of two genes restoring acid phosphatase activity in pho1- mutants of Schizosaccharomyces pombe. Maundrell, K., Nurse, P., Schönholzer, F., Schweingruber, M.E. Gene (1985) [Pubmed]
  7. Acid phosphatase deficient mutants of Schizosaccharomyces pombe are defective in tyrosine uptake. Coddington, A., Schweingruber, M.E. Curr. Genet. (1986) [Pubmed]
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