High impact information on pho1

• Pho4 is not genetically linked to the phosphate repressible acid phosphatase gene pho1 [1].
• In Schizosaccharomyces pombe the 14-3-3 protein Rad24p is involved in negative control of pho1 gene expression [2].
• Strains carrying mutated structural genes for three different phosphatases, pho1, pho2 or pho3, degraded polyphosphate at the same rate as the wild-type strain during phosphate starvation and showed the same type of over-compensation when phosphate was added again [3].
• They define four genes (anr1, anr2, anr3, and anr5) which are involved in adenine-dependent pho1 expression [4].

Biological context of pho1

• Effects of seven different mutations in the pho1 gene on enzymatic activity, glycosylation and secretion of acid phosphatase in Schizosaccharomyces pombe [5].

Associations of pho1 with chemical compounds

• Schizosaccharomyces pombe acid phosphatase (APh) is a secreted cell surface glycoprotein which is deficient in pho1 mutants [6].
• All 11 pho 1-alleles tested exhibited a reduced tyrosine uptake and impaired uptake cosegregated with the lack of acid phosphatase activity [7].

References