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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cd80  -  Cd80 molecule

Rattus norvegicus

 
 
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Disease relevance of Cd80

  • Late blockade of CD28-B7 T cell costimulation by the fusion protein CTLA4Ig, which binds both CD80 and CD86, attenuated the development of transplant arteriosclerosis, mononuclear cell infiltration, and parenchymal fibrosis in this model [1].
 

High impact information on Cd80

  • Recent studies suggest that co-stimulatory molecules B7.1 (CD80) and B7.2 (CD86) play a differential role in the effect of beneficial versus deleterious CNS autoimmune responses [2].
 

Anatomical context of Cd80

  • Presence of spinal B7.2 (CD86) but not B7.1 (CD80) co-stimulatory molecules following peripheral nerve injury: role of nondestructive immunity in neuropathic pain [2].
  • In this study, we used the same model to examine the requirement for CD28-B7-mediated T cell costimulation in the progression of established chronic rejection and examined the individual roles of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules [1].

References

  1. CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis. Kim, K.S., Denton, M.D., Chandraker, A., Knoflach, A., Milord, R., Waaga, A.M., Turka, L.A., Russell, M.E., Peach, R., Sayegh, M.H. Am. J. Pathol. (2001) [Pubmed]
  2. Presence of spinal B7.2 (CD86) but not B7.1 (CD80) co-stimulatory molecules following peripheral nerve injury: role of nondestructive immunity in neuropathic pain. Rutkowski, M.D., Lambert, F., Raghavendra, V., DeLeo, J.A. J. Neuroimmunol. (2004) [Pubmed]
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