Gene Review:
Cd80 - CD80 antigen
Mus musculus
Synonyms:
Activation B7-1 antigen, B7, B7-1, B7.1, B71, ...
- B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Salomon, B., Lenschow, D.J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A., Bluestone, J.A. Immunity (2000)
- B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism. Stremmel, C., Greenfield, E.A., Howard, E., Freeman, G.J., Kuchroo, V.K. J. Exp. Med. (1999)
- Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis. Racke, M.K., Scott, D.E., Quigley, L., Gray, G.S., Abe, R., June, C.H., Perrin, P.J. J. Clin. Invest. (1995)
- Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia. LaBelle, J.L., Hanke, C.A., Blazar, B.R., Truitt, R.L. Blood (2002)
- The B7 family revisited. Greenwald, R.J., Freeman, G.J., Sharpe, A.H. Annu. Rev. Immunol. (2005)
- Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Salomon, B., Bluestone, J.A. Annu. Rev. Immunol. (2001)
- B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Kuchroo, V.K., Das, M.P., Brown, J.A., Ranger, A.M., Zamvil, S.S., Sobel, R.A., Weiner, H.L., Nabavi, N., Glimcher, L.H. Cell (1995)
- Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Chen, L., Ashe, S., Brady, W.A., Hellström, I., Hellström, K.E., Ledbetter, J.A., McGowan, P., Linsley, P.S. Cell (1992)
- CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin. Herold, K.C., Vezys, V., Koons, A., Lenschow, D., Thompson, C., Bluestone, J.A. J. Immunol. (1997)
- B7 requirements for primary and secondary protein- and polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae. Wu, Z.Q., Khan, A.Q., Shen, Y., Schartman, J., Peach, R., Lees, A., Mond, J.J., Gause, W.C., Snapper, C.M. J. Immunol. (2000)
- Involvement of altered B7 expression in dioxin immunotoxicity: B7 transfection restores the CTL but not the autoantibody response to the P815 mastocytoma. Prell, R.A., Kerkvliet, N.I. J. Immunol. (1997)
- Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity. Reiser, H., Schneeberger, E.E. Eur. J. Immunol. (1996)
- Melphalan and other anticancer modalities up-regulate B7-1 gene expression in tumor cells. Sojka, D.K., Donepudi, M., Bluestone, J.A., Mokyr, M.B. J. Immunol. (2000)
- The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3. Reeves, R.H., Patch, D., Sharpe, A.H., Borriello, F., Freeman, G.J., Edelhoff, S., Disteche, C. Mamm. Genome (1997)
- B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Borriello, F., Sethna, M.P., Boyd, S.D., Schweitzer, A.N., Tivol, E.A., Jacoby, D., Strom, T.B., Simpson, E.M., Freeman, G.J., Sharpe, A.H. Immunity (1997)
- Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. Freeman, G.J., Long, A.J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L.J., Malenkovich, N., Okazaki, T., Byrne, M.C., Horton, H.F., Fouser, L., Carter, L., Ling, V., Bowman, M.R., Carreno, B.M., Collins, M., Wood, C.R., Honjo, T. J. Exp. Med. (2000)
- Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells. Gao, J.X., Zhang, H., Bai, X.F., Wen, J., Zheng, X., Liu, J., Zheng, P., Liu, Y. J. Exp. Med. (2002)
- B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Swallow, M.M., Wallin, J.J., Sha, W.C. Immunity (1999)
- CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86. Orabona, C., Grohmann, U., Belladonna, M.L., Fallarino, F., Vacca, C., Bianchi, R., Bozza, S., Volpi, C., Salomon, B.L., Fioretti, M.C., Romani, L., Puccetti, P. Nat. Immunol. (2004)
- Cross-linking CD21/CD35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells. Kozono, Y., Abe, R., Kozono, H., Kelly, R.G., Azuma, T., Holers, V.M. J. Immunol. (1998)
- Adenovirus-mediated gene transfer of CTLA-4Ig fusion protein in the suppression of experimental autoimmune arthritis. Quattrocchi, E., Dallman, M.J., Feldmann, M. Arthritis Rheum. (2000)
- Pancreatic expression of B7 co-stimulatory molecules in the non-obese diabetic mouse. Stephens, L.A., Kay, T.W. Int. Immunol. (1995)
- Microparticulate beta-glucan upregulates the expression of B7.1, B7.2, B7-H1, but not B7-DC on cultured murine peritoneal macrophages. Hunter, K.W., DuPre', S., Redelman, D. Immunol. Lett. (2004)
- Expression of costimulatory molecules: B7 and ICAM up-regulation after treatment with a suicide gene. Ramesh, R., Munshi, A., Abboud, C.N., Marrogi, A.J., Freeman, S.M. Cancer Gene Ther. (1996)
- DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice. Chang, Y., Yap, S., Ge, X., Piganelli, J., Bertera, S., Giannokakis, N., Mathews, C., Prud'homme, G., Trucco, M. Gene Ther. (2005)
- The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice. Wong, F.S., Du, W., Thomas, I.J., Wen, L. Diabetes (2005)
- Melphalan-induced up-regulation of B7-1 surface expression on normal splenic B cells. Donepudi, M., Jovasevic, V.M., Raychaudhuri, P., Mokyr, M.B. Cancer Immunol. Immunother. (2003)
- Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses. Roy, M., Aruffo, A., Ledbetter, J., Linsley, P., Kehry, M., Noelle, R. Eur. J. Immunol. (1995)
- Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice. Stämpfli, M.R., Cwiartka, M., Gajewska, B.U., Alvarez, D., Ritz, S.A., Inman, M.D., Xing, Z., Jordana, M. Am. J. Respir. Cell Mol. Biol. (1999)
- IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. Stack, R.M., Lenschow, D.J., Gray, G.S., Bluestone, J.A., Fitch, F.W. J. Immunol. (1994)
- TLR2 and TLR4 differentially regulate B7-1 resulting in distinct cytokine responses to the mycoplasma superantigen MAM as well as to disease induced by Mycoplasma arthritidis. Mu, H.H., Humphreys, J., Chan, F.V., Cole, B.C. Cell. Microbiol. (2006)
- Upregulation of B7 molecules (CD80 and CD86) and exacerbated eosinophilic pulmonary inflammatory response in mice lacking the IFN-beta gene. Matheu, V., Treschow, A., Navikas, V., Issazadeh-Navikas, S. J. Allergy Clin. Immunol. (2003)
- An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells. Vijayakrishnan, L., Slavik, J.M., Illés, Z., Rainbow, D., Peterson, L.B., Sharpe, A.S., Wicker, L.S., Kuchroo, V.K. Novartis Found. Symp. (2005)
- Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells. Luksch, C.R., Winqvist, O., Ozaki, M.E., Karlsson, L., Jackson, M.R., Peterson, P.A., Webb, S.R. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Contribution of interleukin-12 (IL-12) and the CD28/B7 and CD40/CD40 ligand pathways to the development of a pathological T-cell response in IL-10-deficient mice. Wille, U., Villegas, E.N., Craig, L., Peach, R., Hunter, C.A. Infect. Immun. (2002)
- Gene immunotherapy in murine acute myeloid leukemia: granulocyte-macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and other cytokine vaccines. Dunussi-Joannopoulos, K., Dranoff, G., Weinstein, H.J., Ferrara, J.L., Bierer, B.E., Croop, J.M. Blood (1998)
- Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2. Furukawa, Y., Mandelbrot, D.A., Libby, P., Sharpe, A.H., Mitchell, R.N. Am. J. Pathol. (2000)
- Interleukin-12 and B7.1 co-stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors. Zitvogel, L., Robbins, P.D., Storkus, W.J., Clarke, M.R., Maeurer, M.J., Campbell, R.L., Davis, C.G., Tahara, H., Schreiber, R.D., Lotze, M.T. Eur. J. Immunol. (1996)