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Gene Review:

cut12 - spindle pole body protein Cut12

Schizosaccharomyces pombe 972h-

Hudson, J.D. et al., Bridge, A.J. et al., Petersen, J. et al.

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High impact information on SPBC649.05

The cut12(+) gene encodes a novel 62-kD protein with two predicted coiled coil regions, and one consensus phosphorylation site for p34(cdc2) and two for MAP kinase [1].
stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe [2].
Interaction with various mutants and plasmid overexpression experiments suggest that stf1 does not operate either upstream or downstream of wee1 [2].
Hyper-activating mutations in either cut12 or plo1 enable Cdc25-defective cells to enter mitosis [3].

Other interactions of SPBC649.05

Similarly, it does not operate through cdc25 since it rescues the disruption. stf1 appears to encode an important new element of mitotic control [2].

References

The fission yeast SPB component Cut12 links bipolar spindle formation to mitotic control. Bridge, A.J., Morphew, M., Bartlett, R., Hagan, I.M. Genes Dev. (1998) [Pubmed]
stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe. Hudson, J.D., Feilotter, H., Young, P.G. Genetics (1990) [Pubmed]
Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast. Petersen, J., Hagan, I.M. Nature (2005) [Pubmed]

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