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Gene Review

plo1  -  Polo kinase Plo1

Schizosaccharomyces pombe 972h-

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High impact information on plo1

  • Loss of plo1+ function leads to a mitotic arrest in which condensed chromosomes are associated with a monopolar spindle or to the failure of septation following the completion of nuclear division [1].
  • The overexpression of plo1+ in wild-type cells also results in the formation of monopolar spindles but also induces the formation of multiple septa without nuclear division [1].
  • The fission yeast plo1(+) gene encodes a polo-like kinase, a member of a conserved family of kinases which play multiple roles during the cell cycle [2].
  • A link between Plo1 and the septum initiating network (SIN) has been suggested by the inability of plo1 Delta cells to septate and the prolific septation following plo1(+) overexpression [3].
  • SIN signaling is regulated by the polo-like kinase plo1p and by cdc2p, the initiator of mitosis, and its activation is co-ordinated with other events in mitosis to ensure that cytokinesis does not begin until chromosomes have been separated [4].

Biological context of plo1

  • Hyper-activating mutations in either cut12 or plo1 enable Cdc25-defective cells to enter mitosis [5].

Other interactions of plo1

  • Using this screen, mutations in all the previously described septation initiation network genes were obtained, with the exception of byr4, sid4 and plo1 [6].


  1. The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. Ohkura, H., Hagan, I.M., Glover, D.M. Genes Dev. (1995) [Pubmed]
  2. Polo boxes and Cut23 (Apc8) mediate an interaction between polo kinase and the anaphase-promoting complex for fission yeast mitosis. May, K.M., Reynolds, N., Cullen, C.F., Yanagida, M., Ohkura, H. J. Cell Biol. (2002) [Pubmed]
  3. The role of Plo1 kinase in mitotic commitment and septation in Schizosaccharomyces pombe. Tanaka, K., Petersen, J., MacIver, F., Mulvihill, D.P., Glover, D.M., Hagan, I.M. EMBO J. (2001) [Pubmed]
  4. SIN and the art of splitting the fission yeast cell. Krapp, A., Gulli, M.P., Simanis, V. Curr. Biol. (2004) [Pubmed]
  5. Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast. Petersen, J., Hagan, I.M. Nature (2005) [Pubmed]
  6. Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes. Fournier, N., Cerutti, L., Beltraminelli, N., Salimova, E., Simanis, V. Arch. Microbiol. (2001) [Pubmed]
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