Gene Review:
azr1 - serine/threonine protein phosphatase Azr1
Schizosaccharomyces pombe 972h-
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High impact information on azr1
- We also report the sequence of the putative fission yeast cytidine deaminase gene, designated pcd1+, which lies immediately adjacent to azr1+ but which plays only a moderate role in suppression of 5-azaC sensitivity [1].
- The azr1+ gene is not essential and the null mutant shows no alteration in either DNA repair or checkpoint properties [1].
- Here we describe the isolation of azr1+, as a multi-copy suppressor of the 5-azaC sensitivity of G2 checkpoint and DNA repair-deficient strains. azr1+ encodes a putative 25 kDa protein with limited homology to a Saccharomyces cerevisiae open reading frame of unknown function [1].
References
- Isolation of a Schizosaccharomyces pombe gene which in high copy confers resistance to the nucleoside analogue 5-azacytidine. Platt, G.M., Price, C. Yeast (1997) [Pubmed]
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