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Gene Review

pyp2  -  tyrosine phosphatase Pyp2

Schizosaccharomyces pombe 972h-

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High impact information on pyp2

  • Simultaneous inactivation of pyp1 and pyp2 PTPases in fission yeast leads to aberrant cell morphology and growth arrest [1].
  • We find that wis1-dependent induction of pyp2 mRNA is responsible for tyrosine dephosphorylation of Sty1 in vivo on prolonged exposure to osmotic stress [1].
  • Overexpression of pyp1 or pyp2 delays the onset of mitosis by a wee1-dependent mechanism [2].
  • Disruption of pyp2 has no impact on cell viability, but pyp2 is essential in strains lacking the 60 kDa pyp1 PTPase [2].
  • Spc1 also promotes expression of pyp2+, which encodes a tyrosine phosphatase postulated as a negative regulator of Spc1 [3].


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