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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pyp2  -  tyrosine phosphatase Pyp2

Schizosaccharomyces pombe 972h-

 
 
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High impact information on pyp2

  • Simultaneous inactivation of pyp1 and pyp2 PTPases in fission yeast leads to aberrant cell morphology and growth arrest [1].
  • We find that wis1-dependent induction of pyp2 mRNA is responsible for tyrosine dephosphorylation of Sty1 in vivo on prolonged exposure to osmotic stress [1].
  • Overexpression of pyp1 or pyp2 delays the onset of mitosis by a wee1-dependent mechanism [2].
  • Disruption of pyp2 has no impact on cell viability, but pyp2 is essential in strains lacking the 60 kDa pyp1 PTPase [2].
  • Spc1 also promotes expression of pyp2+, which encodes a tyrosine phosphatase postulated as a negative regulator of Spc1 [3].

References

  1. Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast. Millar, J.B., Buck, V., Wilkinson, M.G. Genes Dev. (1995) [Pubmed]
  2. Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast. Millar, J.B., Russell, P., Dixon, J.E., Guan, K.L. EMBO J. (1992) [Pubmed]
  3. Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe. Degols, G., Shiozaki, K., Russell, P. Mol. Cell. Biol. (1996) [Pubmed]
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