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Gene Review

pyp1  -  tyrosine phosphatase Pyp1

Schizosaccharomyces pombe 972h-

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High impact information on pyp1

  • Simultaneous inactivation of pyp1 and pyp2 PTPases in fission yeast leads to aberrant cell morphology and growth arrest [1].
  • Cells bearing inactive wee1 are unresponsive to disruption of pyp1 [2].
  • Disruption of either gene rescues the G2 arrest caused by mutation of the cdc25 mitotic inducer, though the effect of pyp1-disruption is more pronounced [2].
  • Disruption of pyp2 has no impact on cell viability, but pyp2 is essential in strains lacking the 60 kDa pyp1 PTPase [2].
  • Our data suggest that pyp1+ and pyp2+ act as negative regulators of mitosis upstream of the wee1+/mik1+ pathway [3].

Biological context of pyp1

  • Overexpression of pyp1+ inhibits both transcription of the fbp1 gene, which is negatively regulated by a glucose-induced activation of PKA, and sexual development, which is negatively regulated by PKA through a nitrogen- and glucose-monitoring mechanism [4].

Associations of pyp1 with chemical compounds


Regulatory relationships of pyp1

  • Previous studies suggest that overexpression of pyp1+ results in a mitotic delay by positively regulating wee1 activity [4].

Other interactions of pyp1

  • We show that pyp1 repression of fbp1 transcription is independent of wee1 [4].


  1. Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast. Millar, J.B., Buck, V., Wilkinson, M.G. Genes Dev. (1995) [Pubmed]
  2. Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast. Millar, J.B., Russell, P., Dixon, J.E., Guan, K.L. EMBO J. (1992) [Pubmed]
  3. The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis. Ottilie, S., Chernoff, J., Hannig, G., Hoffman, C.S., Erikson, R.L. Mol. Cell. Biol. (1992) [Pubmed]
  4. The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways. Dal Santo, P., Blanchard, B., Hoffman, C.S. J. Cell. Sci. (1996) [Pubmed]
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