The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

wis1  -  MAP kinase kinase Wis1

Schizosaccharomyces pombe 972h-

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of wis1

  • Heterothalic phh1 dsiruptant is phenotypically indistinguishable from wis1 deletion mutant, both displaying the same extent of partial sterility and enhanced sensitivity to a variety of stress [1].

High impact information on wis1


Biological context of wis1

  • Mutations in the spc1+ and wis1+ genes cause a G2 cell cycle delay that is exacerbated during stress [5].

Associations of wis1 with chemical compounds

  • The wis1+ gene potentially encodes a 66 kDa protein with homology to the serine/threonine family of protein kinases. wis1+ plays an important role in the regulation of entry into mitosis, as it shares with cdc25+ and nim1+/cdr1+ the property of inducing mitosis in a dosage-dependent manner [4].
  • In addition, glyoxalase I activity was increased in stress-activated protein kinase-deficient mutants (wis1 and spc1) [6].

Regulatory relationships of wis1

  • We provide evidence that this osmotic induction of gpd1+ in S. pombe is under the control of a MAP-signaling pathway involving the wis1+ gene-product, which is a homologue of MAP-kinase kinases [7].

Other interactions of wis1

  • Consistent with this, we have found that the wis1 mutation, which is defective in a MAP-kinase kinase of the pathway, suppresses the sts5 mutation [8].


  1. Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast. Kato, T., Okazaki, K., Murakami, H., Stettler, S., Fantes, P.A., Okayama, H. FEBS Lett. (1996) [Pubmed]
  2. Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast. Millar, J.B., Buck, V., Wilkinson, M.G. Genes Dev. (1995) [Pubmed]
  3. Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast. Samejima, I., Mackie, S., Fantes, P.A. EMBO J. (1997) [Pubmed]
  4. The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe. Warbrick, E., Fantes, P.A. EMBO J. (1991) [Pubmed]
  5. Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade. Shiozaki, K., Shiozaki, M., Russell, P. Mol. Biol. Cell (1997) [Pubmed]
  6. Unique regulation of glyoxalase I activity during osmotic stress response in the fission yeast Schizosaccharomyces pombe: neither the mRNA nor the protein level of glyoxalase I increase under conditions that enhance its activity. Takatsume, Y., Izawa, S., Inoue, Y. Arch. Microbiol. (2005) [Pubmed]
  7. The osmo-inducible gpd1+ gene is a target of the signaling pathway involving Wis1 MAP-kinase kinase in fission yeast. Aiba, H., Yamada, H., Ohmiya, R., Mizuno, T. FEBS Lett. (1995) [Pubmed]
  8. The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway. Toda, T., Niwa, H., Nemoto, T., Dhut, S., Eddison, M., Matsusaka, T., Yanagida, M., Hirata, D. J. Cell. Sci. (1996) [Pubmed]
WikiGenes - Universities