The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

Gene Review: 

Slc11a2  -  solute carrier family 11 (proton-coupled...

Rattus norvegicus

Synonyms: DMT-1, Dct1, Divalent cation transporter 1, Divalent metal transporter 1, Dmt1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Slc11a2

  • Differential expression of divalent metal transporter DMT1 (Slc11a2) in the spermatogenic epithelium of the developing and adult rat testis [1].
  • Alterations in iron levels are likely to influence the biological actions of Mn in PC12 cells, because both metals are transported via the divalent metal transporter 1 (DMT1; also Nramp2 or DCT1) [2].
  • The ubiquitously expressed gene Nramp2 is an Fe(2+) transporter and a mutation in this gene causes microcytic anaemia in mice and rats [3].
  • Transferrin-dependent iron uptake is defective because of a mutation in Nramp2 (now DMT1, also called DCT1), the protein responsible for endosomal iron efflux [4].

References

  1. Differential expression of divalent metal transporter DMT1 (Slc11a2) in the spermatogenic epithelium of the developing and adult rat testis. Griffin, K.P., Ward, D.T., Liu, W., Stewart, G., Morris, I.D., Smith, C.P. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  2. Effect of the iron chelator desferrioxamine on manganese-induced toxicity of rat pheochromocytoma (PC12) cells. Roth, J.A., Feng, L., Dolan, K.G., Lis, A., Garrick, M.D. J. Neurosci. Res. (2002) [Pubmed]
  3. The natural resistance-associated macrophage protein and susceptibility to intracellular pathogens. Bellamy, R. Microbes Infect. (1999) [Pubmed]
  4. Evidence for and consequences of chronic heme deficiency in Belgrade rat reticulocytes. Garrick, M.D., Scott, D., Kulju, D., Romano, M.A., Dolan, K.G., Garrick, L.M. Biochim. Biophys. Acta (1999) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities