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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Gnaz  -  guanine nucleotide binding protein (G...

Rattus norvegicus

Synonyms: G(x) alpha chain, Guanine nucleotide-binding protein G(z) subunit alpha, Gz-alpha
 
 
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High impact information on Gnaz

  • Gi1 alpha was expressed in RPT of SHR and WKY rats to the same levels, but neither G(o) alpha nor Gz alpha was detected in these membranes; higher (50%) expression levels of Gi2 alpha were found in SHR [1].
  • Mature adipocytes express Gi alpha 1, Gi alpha 2, Gi alpha 3, Go alpha, Gq/11 alpha, G13 alpha and the long and short isoforms of Gs alpha, but no Gz alpha or G12 alpha [2].
  • Gz alpha/Gx alpha mRNA was expressed in all pituitary cell lines as well as in pituitary tissue [3].

References

  1. Increased expression of inhibitory guanine nucleotide binding proteins in membranes from renal proximal tubules, but not brain striata, of the normotensive and the spontaneously hypertensive rat. White, B.H., Sidhu, A. J. Hypertens. (1996) [Pubmed]
  2. G proteins in adipocytes and preadipocytes: characterization, subcellular distribution, and potential roles for Gi2 and/or Gi3 in the control of cell proliferation. Denis-Henriot, D., de Mazancourt, P., Goldsmith, P.K., Giudicelli, Y. Cell. Signal. (1996) [Pubmed]
  3. Cell specific distribution of guanine nucleotide-binding regulatory proteins in rat pituitary tumour cell lines. Paulssen, E.J., Paulssen, R.H., Haugen, T.B., Gautvik, K.M., Gordeladze, J.O. Mol. Cell. Endocrinol. (1991) [Pubmed]
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