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MeSH Review

Rats, Inbred WKY

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Disease relevance of Rats, Inbred WKY


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Chemical compound and disease context of Rats, Inbred WKY


Biological context of Rats, Inbred WKY


Anatomical context of Rats, Inbred WKY


Associations of Rats, Inbred WKY with chemical compounds

  • Moreover, male WKY rats castrated as weanlings and normal adult female WKY rats each implanted with testosterone displayed significant (P less than 0.05) increases in renal ang-n mRNA levels [28].
  • Active wall tension induced by angiotensin I 10(-7) mol/L was increased in older SHR (0.19 +/- 0.04, n = 7) compared with younger SHR (0.04 +/- 0.01, n = 9) but was similar in younger and older WKY rats (0.10 +/- 0.02 versus 0.15 +/- 0.03, n = 6 to 9) and younger SHR [24].
  • METHODS AND RESULTS: Male SHR and normotensive Wistar-Kyoto rats (WKY) were assigned to no treatment or captopril treatment (2 g/L in drinking water) begun at ages 12, 18, and 21 months; animals were studied at 24 months of age, or earlier when evidence of heart failure was found in SHR (mean age, 19+/-2 months) [29].
  • In both strains, active wall tension to endothelin-1 and serotonin increased with age (n = 6 to 10, P < .05) but was decreased in younger and older SHR compared with WKY rats (P < .05) [24].
  • To determine whether similar differences in regression of wall thickening also occur in resistance vessels during treatment, matched groups of spontaneously hypertensive rats (SHR) were treated for 12 weeks with either hydralazine (H) or captopril and hydrochlorothiazide (C-D) and they were compared with untreated SHR and Wistar-Kyoto rats (WKY) [30].

Gene context of Rats, Inbred WKY


Analytical, diagnostic and therapeutic context of Rats, Inbred WKY


  1. In vivo inhibition of CC and CX3C chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in Wistar-Kyoto (WKY) rats by vMIP-II. Chen, S., Bacon, K.B., Li, L., Garcia, G.E., Xia, Y., Lo, D., Thompson, D.A., Siani, M.A., Yamamoto, T., Harrison, J.K., Feng, L. J. Exp. Med. (1998) [Pubmed]
  2. Intestinal phosphate transport in spontaneously hypertensive rats and genetically matched controls. Ghishan, F.K., Arab, N., Shibata, H. Gastroenterology (1990) [Pubmed]
  3. Effect of chronic dihydropyridine (isradipine) on the large arterial walls of spontaneously hypertensive rats. Levy, B.I., Duriez, M., Phillipe, M., Poitevin, P., Michel, J.B. Circulation (1994) [Pubmed]
  4. Development of left ventricular hypertrophy in young spontaneously hypertensive rats after peripheral sympathectomy. Cutilletta, A.F., Erinoff, L., Heller, A., Low, J., Oparil, S. Circ. Res. (1977) [Pubmed]
  5. The economy of isometric force development, myosin isoenzyme pattern and myofibrillar ATPase activity in normal and hypothyroid rat myocardium. Holubarsch, C., Goulette, R.P., Litten, R.Z., Martin, B.J., Mulieri, L.A., Alpert, N.R. Circ. Res. (1985) [Pubmed]
  6. Genetics of behaviour: phenotypic and molecular study of rats derived from high- and low-alcohol consuming lines. Terenina-Rigaldie, E., Moisan, M.P., Colas, A., Beaugé, F., Shah, K.V., Jones, B.C., Mormède, P. Pharmacogenetics (2003) [Pubmed]
  7. The effect of dietary fish oil and salt on blood pressure and eicosanoid metabolism of spontaneously hypertensive rats. Codde, J.P., Beilin, L.J., Croft, K.D., Vandongen, R. J. Hypertens. (1987) [Pubmed]
  8. Effects of propentofylline on disorder of learning and memory in rodents. Goto, M., Demura, N., Sakaguchi, T. Jpn. J. Pharmacol. (1987) [Pubmed]
  9. Potentiation of dipsogenic actions by centrally administered type-C natriuretic peptide in spontaneously hypertensive but not Wistar-Kyoto rats. Goto, E., Shibata, K., Furukawa, T. Clin. Exp. Pharmacol. Physiol. (1997) [Pubmed]
  10. Strain-dependent modification of behavior following antidepressant treatment. Tejani-Butt, S., Kluczynski, J., Paré, W.P. Prog. Neuropsychopharmacol. Biol. Psychiatry (2003) [Pubmed]
  11. Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. Cosentino, F., Patton, S., d'Uscio, L.V., Werner, E.R., Werner-Felmayer, G., Moreau, P., Malinski, T., Lüscher, T.F. J. Clin. Invest. (1998) [Pubmed]
  12. Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats. Bokemeyer, D., Guglielmi, K.E., McGinty, A., Sorokin, A., Lianos, E.A., Dunn, M.J. J. Clin. Invest. (1997) [Pubmed]
  13. Coagulation factor Xa stimulates platelet-derived growth factor release and mitogenesis in cultured vascular smooth muscle cells of rat. Ko, F.N., Yang, Y.C., Huang, S.C., Ou, J.T. J. Clin. Invest. (1996) [Pubmed]
  14. Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy. Negoro, N., Kanayama, Y., Haraguchi, M., Umetani, N., Nishimura, M., Konishi, Y., Iwai, J., Okamura, M., Inoue, T., Takeda, T. J. Clin. Invest. (1995) [Pubmed]
  15. Adrenoreceptor blockade in angiotensin-induced hypertension: effect on rat coronary arteries and myocardium. Bhan, R.D., Giacomelli, F., Wiener, J. Am. J. Pathol. (1982) [Pubmed]
  16. Receptor-mediated effects of angiotensin II on growth of vascular smooth muscle cells from spontaneously hypertensive rats. Bunkenburg, B., van Amelsvoort, T., Rogg, H., Wood, J.M. Hypertension (1992) [Pubmed]
  17. Molecular mechanism of angiotensin II type I and type II receptors in cardiac hypertrophy of spontaneously hypertensive rats. Makino, N., Sugano, M., Otsuka, S., Hata, T. Hypertension (1997) [Pubmed]
  18. Effects of moderate diabetes on cardiac performance in spontaneously hypertensive and Wistar-Kyoto rats. Yamamoto, J., Nakai, M. Hypertension (1988) [Pubmed]
  19. Possible involvement of brain opioid peptides in clonidine-induced hypotension in spontaneously hypertensive rats. van Giersbergen, P.L., Tierney, S.A., Wiegant, V.M., de Jong, W. Hypertension (1989) [Pubmed]
  20. Endothelial function in deoxycorticosterone-NaCl hypertension: effect of calcium supplementation. Mäkynen, H., Kähönen, M., Wu, X., Arvola, P., Pörsti, I. Circulation (1996) [Pubmed]
  21. Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. Monti, J., Plehm, R., Schulz, H., Ganten, D., Kreutz, R., Hübner, N. Hum. Mol. Genet. (2003) [Pubmed]
  22. Systemic and regional hemodynamic effects of acute and prolonged treatment with urapidil or prazosin in normotensive and spontaneously hypertensive rats. Pegram, B.L., Kobrin, I., Natsume, T., Gallo, A.J., Frohlich, E.D. Am. J. Med. (1984) [Pubmed]
  23. Increased Na(+)-H+ exchange in jejunal brush border membrane vesicles of spontaneously hypertensive rats. Acra, S., Ghishan, F.K. Gastroenterology (1991) [Pubmed]
  24. Age and hypertension differently affect coronary contractions to endothelin-1, serotonin, and angiotensins. Tschudi, M.R., Lüscher, T.F. Circulation (1995) [Pubmed]
  25. Increased angiotensin II binding affinity in the nucleus tractus solitarius of spontaneously hypertensive rats. Plunkett, L.M., Saavedra, J.M. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  26. Endothelium-dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H2 in the SHR aorta. Ge, T., Hughes, H., Junquero, D.C., Wu, K.K., Vanhoutte, P.M., Boulanger, C.M. Circ. Res. (1995) [Pubmed]
  27. Neuronal nitric oxide synthase is expressed in rat vascular smooth muscle cells: activation by angiotensin II in hypertension. Boulanger, C.M., Heymes, C., Benessiano, J., Geske, R.S., Lévy, B.I., Vanhoutte, P.M. Circ. Res. (1998) [Pubmed]
  28. Androgen regulation of rat renal angiotensinogen messenger RNA expression. Ellison, K.E., Ingelfinger, J.R., Pivor, M., Dzau, V.J. J. Clin. Invest. (1989) [Pubmed]
  29. Effect of angiotensin-converting enzyme inhibition on myocardial fibrosis and function in hypertrophied and failing myocardium from the spontaneously hypertensive rat. Brooks, W.W., Bing, O.H., Robinson, K.G., Slawsky, M.T., Chaletsky, D.M., Conrad, C.H. Circulation (1997) [Pubmed]
  30. Differential structural responses of small resistance vessels to antihypertensive therapy. Sano, T., Tarazi, R.C. Circulation (1987) [Pubmed]
  31. Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats. Ndisang, J.F., Wu, L., Zhao, W., Wang, R. Blood (2003) [Pubmed]
  32. Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion. Schäfer, A., Schulz, C., Eigenthaler, M., Fraccarollo, D., Kobsar, A., Gawaz, M., Ertl, G., Walter, U., Bauersachs, J. Blood (2004) [Pubmed]
  33. Peptide-containing nerves around blood vessels of stroke-prone spontaneously hypertensive rats. Lee, R.M., Nagahama, M., McKenzie, R., Daniel, E.E. Hypertension (1988) [Pubmed]
  34. Transforming growth factor-beta and receptor tyrosine kinase-activating growth factors negatively regulate collagen genes in smooth muscle of hypertensive rats. Bray, P., Agrotis, A., Bobik, A. Hypertension (1998) [Pubmed]
  35. Na(+)-H+ exchanger isoform 1 phosphorylation in normal Wistar-Kyoto and spontaneously hypertensive rats. Siczkowski, M., Davies, J.E., Ng, L.L. Circ. Res. (1995) [Pubmed]
  36. Enhanced glucose tolerance in spontaneously hypertensive rats. Pancreatic beta-cell hyperfunction with normal insulin sensitivity. Buchanan, T.A., Youn, J.H., Campese, V.M., Sipos, G.F. Diabetes (1992) [Pubmed]
  37. Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: an event that precedes hypertrophy development. Benderdour, M., Charron, G., DeBlois, D., Comte, B., Des Rosiers, C. J. Biol. Chem. (2003) [Pubmed]
  38. Differential expression of Smad7 transcripts identifies the CD4+CD45RChigh regulatory T cells that mediate type V collagen-induced tolerance to lung allografts. Mizobuchi, T., Yasufuku, K., Zheng, Y., Haque, M.A., Heidler, K.M., Woods, K., Smith, G.N., Cummings, O.W., Fujisawa, T., Blum, J.S., Wilkes, D.S. J. Immunol. (2003) [Pubmed]
  39. Hypothalamic GABA and sympathetic regulation in spontaneously hypertensive rats. Wible, J.H., DiMicco, J.A., Luft, F.C. Hypertension (1989) [Pubmed]
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