Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

GAGE7 - G antigen 7

Homo sapiens

Synonyms: AL4, CT4.7, Cancer/testis antigen 4.7, GAGE-12I, GAGE-7, ...

Chen, M.E. et al., Cilensek, Z.M. et al.

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Disease relevance of GAGE7

Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens [1].

High impact information on GAGE7

Neither GAGE-7 nor PAGE-1 demonstrated any regulation by androgens in the prostate cancer cell lines used in this study [1].
A GenBankTM data base search using the GCG Wisconsin software package revealed the shorter approximately 600-bp transcript (designated GAGE-7) to be a new member of the GAGE family [1].
Similarly, transfection of GAGE-7/7B also confers resistance to Fas induced apoptosis [2].

Anatomical context of GAGE7

PAGE-1 and GAGE-7 expression was found to be restricted to testes (high) and placenta (low) on human multiple tissue Northern blots [1].

References

Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. Chen, M.E., Lin, S.H., Chung, L.W., Sikes, R.A. J. Biol. Chem. (1998) [Pubmed]
A member of the GAGE family of tumor antigens is an anti-apoptotic gene that confers resistance to Fas/CD95/APO-1, Interferon-gamma, taxol and gamma-irradiation. Cilensek, Z.M., Yehiely, F., Kular, R.K., Deiss, L.P. Cancer Biol. Ther. (2002) [Pubmed]

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