Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

BRI3 - brain protein I3

Homo sapiens

Synonyms: Brain protein I3, pRGR2

Wu, H. et al., Ye, Q. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on BRI3

Analysis of cell death caused by other apoptotic inducers showed that the effect of BRI3 antisense RNA is highly specific to TNF-induced cell death [1].
Previous studies showed that overexpression of BRI3 induced apoptosis in L929 cells [1].
Finally, we reported here that BRI3 may be localized to lysosome and function through lysosome [1].
The antisense RNA promoted resistance to TNF-induced cell death by more than 1000-fold in L929 cells, suggesting the involvement of BRI3 in TNF-induced cell death in this cell line [1].

Analytical, diagnostic and therapeutic context of BRI3

Crystallization and preliminary X-ray analysis of the GST-fused human Bri3 N-terminal domain [2].

References

bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. Wu, H., Liu, G., Li, C., Zhao, S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
Crystallization and preliminary X-ray analysis of the GST-fused human Bri3 N-terminal domain. Ye, Q., Singh, V.K., Blonde, J.D., Jia, Z. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.