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Gene Review

POLR1A  -  polymerase (RNA) I polypeptide A, 194kDa

Homo sapiens

Synonyms: A190, DKFZP586M0122, DNA-directed RNA polymerase I largest subunit, DNA-directed RNA polymerase I subunit A, DNA-directed RNA polymerase I subunit RPA1, ...
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High impact information on POLR1A

  • In this study, we demonstrated that the largest subunit of RNA polymerase I, RPA194, was coimmunoprecipitated with the human Nopp140 (hNopp140) [1].
  • Photochemical cross-linking of human replication protein A (hRPA) to oligonucleotide dT(30) was performed to enable identification of amino acid sequences that reside in the DNA-binding domain [2].
  • Protein factors such as hRad52, hRad54, hRPA, and p53 may modulate the heteroduplex formation and participate in the activation of the endogenous mismatch repair and/or nucleotide excision repair pathway(s) [3].


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