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Gene Review

NOLC1  -  nucleolar and coiled-body phosphoprotein 1

Homo sapiens

Synonyms: 140 kDa nucleolar phosphoprotein, HCV NS5A-transactivated protein 13, Hepatitis C virus NS5A-transactivated protein 13, KIAA0035, NOPP130, ...
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Disease relevance of NOLC1

  • The sequence of Nopp140 contains several stretches of serine- and acidic amino acid-rich sequences which are also found in ICP4 of herpes simplex virus type 1, a known transcription factor that interacts with TFIIB [1].
  • In summary, we demonstrate the existence of a novel Nopp140-mediated PKA signaling pathway that leads to the activation of agp, one of the major acute phase response genes [2].
  • Identification of hNopp140 as a binding partner for doxorubicin with a phage display cloning method [3].
  • In this paper, we report the cloning and overexpression of the soluble form of hNopp140 in Escherichia coli [4].

High impact information on NOLC1

  • As a final link, we identified the coiled body-specific protein p80 coilin in a yeast two-hybrid screen with Nopp140 [5].
  • Taken together, Nopp140 appeared to shuttle between the nucleolus and the coiled bodies, and to chaperone the transport of other molecules [5].
  • The alternating positively and negatively charged repeat domain of Nopp140 was required for targeting to both organelles [5].
  • They contain a subset of splicing snRNPs and several nucleolar antigens, including Nopp140 and fibrillarin [6].
  • A previous study [Meier, U. T. & Blobel, G. (1992) Cell 70, 127-138] has shown that the nucleolar protein of rat liver cells (Nopp140) shuttles from the nucleolus to the nuclear envelope on distinct tracks [7].

Chemical compound and disease context of NOLC1


Biological context of NOLC1


Anatomical context of NOLC1

  • The nucleolar channel system exhibits an ultrastructure that is indistinguishable from R-rings, and nuclei of human endometrium harbor Nopp140 and ER marker containing structures [11].
  • Intranuclear endoplasmic reticulum induced by Nopp140 mimics the nucleolar channel system of human endometrium [11].
  • The superposition of (32)P-labelled ecto-nucleolar phosphoprotein p140 (ecto-Nopp140) with anti-Nopp140 immunostaining could be demonstrated in a wide range of cell lines without any exceptions, suggesting a nearly universal occurrence of cell-surface Nopp140 [12].
  • The number of motor units in the gastrocnemius muscle was progressively reduced over time, down to 18% of the control value at P130 [13].

Associations of NOLC1 with chemical compounds

  • These results suggested that doxorubicin might disrupt the cellular function of hNopp140 [3].
  • One of the putative proteins, YKR412, is very rich in serine and has significant homology at the carboxyl end to Nopp140 phosphoprotein [14].

Physical interactions of NOLC1


Co-localisations of NOLC1


Regulatory relationships of NOLC1

  • Ecto-protein kinase substrate p120 revealed as the cell-surface-expressed nucleolar phosphoprotein Nopp140: a candidate protein for extracellular Ca2+-sensing [12].

Other interactions of NOLC1

  • In this study, we demonstrated that the largest subunit of RNA polymerase I, RPA194, was coimmunoprecipitated with the human Nopp140 (hNopp140) [8].
  • Furthermore, maximal activation of the agp gene by PKA-phosphorylated Nopp140 depends on the presence of CREB and C/EBPbeta [2].
  • The finding of LisH motifs in both treacle and Nopp140 reinforces previous observations of functional similarities between these nucleolar proteins [16].
  • DAO-5 shows 33 % identity with human nucleolar phosphoprotein P130. dao-7 is similar to the mammalian ZFP36 protein [17].
  • The best-studied representatives of this group are Nopp140 and nucleolin, proteins with structural and regulatory functions in rDNA transcription [18].

Analytical, diagnostic and therapeutic context of NOLC1


  1. Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor. Miau, L.H., Chang, C.J., Tsai, W.H., Lee, S.C. Mol. Cell. Biol. (1997) [Pubmed]
  2. Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene. Chiu, C.M., Tsay, Y.G., Chang, C.J., Lee, S.C. J. Biol. Chem. (2002) [Pubmed]
  3. Identification of hNopp140 as a binding partner for doxorubicin with a phage display cloning method. Jin, Y., Yu, J., Yu, Y.G. Chem. Biol. (2002) [Pubmed]
  4. Purification and characterization of human nucleolar phosphoprotein 140 expressed in Escherichia coli. Kim, Y.K., Jin, Y., Vukoti, K.M., Park, J.K., Kim, E.E., Lee, K.J., Yu, Y.G. Protein Expr. Purif. (2003) [Pubmed]
  5. Nopp140 functions as a molecular link between the nucleolus and the coiled bodies. Isaac, C., Yang, Y., Meier, U.T. J. Cell Biol. (1998) [Pubmed]
  6. Mutational analysis of p80 coilin indicates a functional interaction between coiled bodies and the nucleolus. Bohmann, K., Ferreira, J.A., Lamond, A.I. J. Cell Biol. (1995) [Pubmed]
  7. Highly localized tracks of human immunodeficiency virus type 1 Nef in the nucleus of cells of a human CD4+ T-cell line. Murti, K.G., Brown, P.S., Ratner, L., Garcia, J.V. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  8. Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization. Chen, H.K., Pai, C.Y., Huang, J.Y., Yeh, N.H. Mol. Cell. Biol. (1999) [Pubmed]
  9. Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation. Miau, L.H., Chang, C.J., Shen, B.J., Tsai, W.H., Lee, S.C. J. Biol. Chem. (1998) [Pubmed]
  10. Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis. Pai, C.Y., Chen, H.K., Sheu, H.L., Yeh, N.H. J. Cell. Sci. (1995) [Pubmed]
  11. Intranuclear endoplasmic reticulum induced by Nopp140 mimics the nucleolar channel system of human endometrium. Isaac, C., Pollard, J.W., Meier, U.T. J. Cell. Sci. (2001) [Pubmed]
  12. Ecto-protein kinase substrate p120 revealed as the cell-surface-expressed nucleolar phosphoprotein Nopp140: a candidate protein for extracellular Ca2+-sensing. Kübler, D. Biochem. J. (2001) [Pubmed]
  13. Progressive motor neuron impairment in an animal model of familial amyotrophic lateral sclerosis. Azzouz, M., Leclerc, N., Gurney, M., Warter, J.M., Poindron, P., Borg, J. Muscle Nerve (1997) [Pubmed]
  14. The complete sequence of a 15,820 bp segment of Saccharomyces cerevisiae chromosome XI contains the UBI2 and MPL1 genes and three new open reading frames. Bou, G., Esteban, P.F., Baladron, V., Gonzalez, G.A., Cantalejo, J.G., Remacha, M., Jimenez, A., Del Rey, F., Ballesta, J.P., Revuelta, J.L. Yeast (1993) [Pubmed]
  15. Characterization of the nucleolar gene product, treacle, in Treacher Collins syndrome. Isaac, C., Marsh, K.L., Paznekas, W.A., Dixon, J., Dixon, M.J., Jabs, E.W., Meier, U.T. Mol. Biol. Cell (2000) [Pubmed]
  16. A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration. Emes, R.D., Ponting, C.P. Hum. Mol. Genet. (2001) [Pubmed]
  17. DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs. Yu, H., Larsen, P.L. J. Mol. Biol. (2001) [Pubmed]
  18. A novel protein localized to the fibrillar compartment of the nucleolus and to the brush border of a secretory cell. Sun, X., Zhao, J., Jin, S., Palka, K., Visa, N., Aissouni, Y., Daneholt, B., Alzhanova-Ericsson, A.T. Eur. J. Cell Biol. (2002) [Pubmed]
  19. Doxorubicin Binds to Un-phosphorylated Form of hNopp140 and Reduces Protein Kinase CK2-Dependent Phosphorylation of hNopp140. Kim, Y.K., Lee, W.K., Jin, Y., Lee, K.J., Jeon, H., Yu, Y.G. J. Biochem. Mol. Biol. (2006) [Pubmed]
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