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Gene Review

ALS2CL  -  ALS2 C-terminal like

Homo sapiens

Synonyms: ALS2 C-terminal-like protein, DKFZp686I0110, FLJ36525, RN49018
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High impact information on ALS2CL

  • These results suggest that ALS2CL is a novel factor modulating the Rab5-mediated endosome dynamics in the cells [1].
  • In HeLa cells, co-expression of ALS2CL and Rab5A resulted in a unique tubulation phenotype of endosome compartments with significant colocalization of ALS2CL and Rab5A [1].
  • In cultured cells, overexpressed ALS2CL is colocalized with ALS2 onto membranous compartments [2].
  • Computational genomic analysis identified ALS2CL, which is a novel protein highly homologous to the C-terminal region of ALS2 [3].

Anatomical context of ALS2CL

  • ALS2, the causative gene product for a number of recessive motor neuron diseases, is a guanine-nucleotide exchange factor for Rab5, and acts as a modulator for endosome dynamics [2].


  1. ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics. Hadano, S., Otomo, A., Suzuki-Utsunomiya, K., Kunita, R., Yanagisawa, Y., Showguchi-Miyata, J., Mizumura, H., Ikeda, J.E. FEBS Lett. (2004) [Pubmed]
  2. ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics. Suzuki-Utsunomiya, K., Hadano, S., Otomo, A., Kunita, R., Mizumura, H., Osuga, H., Ikeda, J.E. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  3. Purification and functional analyses of ALS2 and its homologue. Hadano, S., Ikeda, J.E. Meth. Enzymol. (2005) [Pubmed]
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