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Gene Review:

GEMIN5 - gem (nuclear organelle) associated protein 5

Homo sapiens

Synonyms: Gem-associated protein 5, Gemin5

Fierro-Monti, I. et al., Battle, D.J. et al., Gubitz, A.K. et al.

Fierro-Monti, Mohammed, Matthiesen, Santoro, Burns, Williams, Proud, Kassem, Jensen, Roepstorff,

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Disease relevance of GEMIN5

Gemin5 and eIF4E co-localized to cytoplasmic P-bodies in human osteosarcoma U2OS cells [1].

High impact information on GEMIN5

We show here that Gemin5, a 170 kDa WD-repeat protein, is the snRNA binding protein of the SMN complex [2].
Gemin5 therefore functions as the factor that allows the SMN complex to distinguish snRNAs from other cellular RNAs for snRNP biogenesis [2].
Quantitative proteomics identifies Gemin5, a scaffolding protein involved in ribonucleoprotein assembly, as a novel partner for eukaryotic initiation factor 4E [1].

Other interactions of GEMIN5

Here, we report the identification of an additional component of the SMN complex, a novel WD repeat protein termed Gemin5 [3].

References

Quantitative proteomics identifies Gemin5, a scaffolding protein involved in ribonucleoprotein assembly, as a novel partner for eukaryotic initiation factor 4E. Fierro-Monti, I., Mohammed, S., Matthiesen, R., Santoro, R., Burns, J.S., Williams, D.J., Proud, C.G., Kassem, M., Jensen, O.N., Roepstorff, P. J. Proteome Res. (2006) [Pubmed]
The Gemin5 protein of the SMN complex identifies snRNAs. Battle, D.J., Lau, C.K., Wan, L., Deng, H., Lotti, F., Dreyfuss, G. Mol. Cell (2006) [Pubmed]
Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins. Gubitz, A.K., Mourelatos, Z., Abel, L., Rappsilber, J., Mann, M., Dreyfuss, G. J. Biol. Chem. (2002) [Pubmed]

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GEMIN5	Bos taurus
GEMIN5	Canis lupus familiaris
gemin5	Danio rerio
GEMIN5	Gallus gallus
GEMIN5	Macaca mulatta
Gemin5	Mus musculus
GEMIN5	Pan troglodytes
Gemin5	Rattus norvegicus
gemin5	Xenopus (Silurana) tropicalis

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