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Gene Review

WDR1  -  WD repeat domain 1

Homo sapiens

Synonyms: AIP1, Actin-interacting protein 1, HEL-S-52, NORI-1, WD repeat-containing protein 1
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Disease relevance of WDR1


Psychiatry related information on WDR1

  • Badia-Elder; (3) The gut peptide cholecystokinin controls alcohol intake in Sardinian alcohol-preferring rats, by Nori Geary and Maurizio Massi; and (4) Hypothalamic galanin: a possible role in excess alcohol drinking, by Sarah F [6].

High impact information on WDR1


Chemical compound and disease context of WDR1

  • The rats were fed with 4 g of the control diet or 4 g of the nori diet containing a standard dioxin solution (233 ngTEQ/kg of body weight) for five consecutive days [12].

Biological context of WDR1


Anatomical context of WDR1


Associations of WDR1 with chemical compounds


Physical interactions of WDR1


Regulatory relationships of WDR1


Other interactions of WDR1


Analytical, diagnostic and therapeutic context of WDR1


  1. Subcellular localization of WD40 repeat 1 protein in PC12 rat pheochromocytoma cells. Shin, D.H., Lee, E., Chung, Y.H., Mun, G.H., Park, J., Lomax, M.I., Oh, S.H. Neurosci. Lett. (2004) [Pubmed]
  2. Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. Brieher, W.M., Kueh, H.Y., Ballif, B.A., Mitchison, T.J. J. Cell Biol. (2006) [Pubmed]
  3. Feline immunodeficiency virus integration in B-cell lymphoma identifies a candidate tumor suppressor gene on human chromosome 15q15. Beatty, J., Terry, A., MacDonald, J., Gault, E., Cevario, S., O'Brien, S.J., Cameron, E., Neil, J.C. Cancer Res. (2002) [Pubmed]
  4. Structural Organization of the WD repeat protein-encoding gene HIRA in the DiGeorge syndrome critical region of human chromosome 22. Lorain, S., Demczuk, S., Lamour, V., Toth, S., Aurias, A., Roe, B.A., Lipinski, M. Genome Res. (1996) [Pubmed]
  5. Endonuclein is a cell cycle regulated WD-repeat protein that is up-regulated in adenocarcinoma of the pancreas. Honoré, B., Baandrup, U., Nielsen, S., Vorum, H. Oncogene (2002) [Pubmed]
  6. Overlapping peptide control of alcohol self-administration and feeding. Thiele, T.E., Stewart, R.B., Badia-Elder, N.E., Geary, N., Massi, M., Leibowitz, S.F., Hoebel, B.G., Egli, M. Alcohol. Clin. Exp. Res. (2004) [Pubmed]
  7. Mutant WD-repeat protein in triple-A syndrome. Tullio-Pelet, A., Salomon, R., Hadj-Rabia, S., Mugnier, C., de Laet, M.H., Chaouachi, B., Bakiri, F., Brottier, P., Cattolico, L., Penet, C., Bégeot, M., Naville, D., Nicolino, M., Chaussain, J.L., Weissenbach, J., Munnich, A., Lyonnet, S. Nat. Genet. (2000) [Pubmed]
  8. FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Adam-Klages, S., Adam, D., Wiegmann, K., Struve, S., Kolanus, W., Schneider-Mergener, J., Krönke, M. Cell (1996) [Pubmed]
  9. The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH. Henning, K.A., Li, L., Iyer, N., McDaniel, L.D., Reagan, M.S., Legerski, R., Schultz, R.A., Stefanini, M., Lehmann, A.R., Mayne, L.V., Friedberg, E.C. Cell (1995) [Pubmed]
  10. Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression. Park, J., Lee, B.S., Choi, J.K., Means, R.E., Choe, J., Jung, J.U. Immunity (2002) [Pubmed]
  11. The Gemin5 protein of the SMN complex identifies snRNAs. Battle, D.J., Lau, C.K., Wan, L., Deng, H., Lotti, F., Dreyfuss, G. Mol. Cell (2006) [Pubmed]
  12. Increasing effect of nori on the fecal excretion of dioxin by rats. Morita, K., Tobiishi, K. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
  13. A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein. Adler, H.J., Winnicki, R.S., Gong, T.W., Lomax, M.I. Genomics (1999) [Pubmed]
  14. Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene. Li, D., Burch, P., Gonzalez, O., Kashork, C.D., Shaffer, L.G., Bachinski, L.L., Roberts, R. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  15. The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C. elegans. Pflugrad, A., Meir, J.Y., Barnes, T.M., Miller, D.M. Development (1997) [Pubmed]
  16. Responses of nociceptive SI neurons in monkeys and pain sensation in humans elicited by noxious thermal stimulation: effect of interstimulus interval. Chudler, E.H., Anton, F., Dubner, R., Kenshalo, D.R. J. Neurophysiol. (1990) [Pubmed]
  17. AIP1/WDR1 supports mitotic cell rounding. Fujibuchi, T., Abe, Y., Takeuchi, T., Imai, Y., Kamei, Y., Murase, R., Ueda, N., Shigemoto, K., Yamamoto, H., Kito, K. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  18. Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo. Gori, F., Friedman, L., Demay, M.B. Journal of musculoskeletal & neuronal interactions. (2005) [Pubmed]
  19. RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. Liu, Z., Sekito, T., Epstein, C.B., Butow, R.A. EMBO J. (2001) [Pubmed]
  20. Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration. Kiely, P.A., O'Gorman, D., Luong, K., Ron, D., O'Connor, R. Mol. Cell. Biol. (2006) [Pubmed]
  21. p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. Vadlamudi, R.K., Li, F., Barnes, C.J., Bagheri-Yarmand, R., Kumar, R. EMBO Rep. (2004) [Pubmed]
  22. A temperature-sensitive mutation in the WD repeat-containing protein Smu1 is related to maintenance of chromosome integrity. Sugaya, K., Hongo, E., Tsuji, H. Exp. Cell Res. (2005) [Pubmed]
  23. A deduced Thermomonospora curvata protein containing serine/threonine protein kinase and WD-repeat domains. Janda, L., Tichý, P., Spízek, J., Petrícek, M. J. Bacteriol. (1996) [Pubmed]
  24. More than a 100-fold increase in immunoblot signals of laser-microdissected inclusion bodies with an excessive aggregation property by oligomeric actin interacting protein 2/D-lactate dehydrogenase protein 2. Hachiya, N.S., Ohkubo, T., Kozuka, Y., Yamazaki, M., Mori, O., Mizusawa, H., Sakasegawa, Y., Kaneko, K. Anal. Biochem. (2005) [Pubmed]
  25. Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. Furuno, K., Masatsugu, T., Sonoda, M., Sasazuki, T., Yamamoto, K. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  26. Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5. Steele, M.R., McCahill, A., Thompson, D.S., MacKenzie, C., Isaacs, N.W., Houslay, M.D., Bolger, G.B. Cell. Signal. (2001) [Pubmed]
  27. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. Ohtoshi, A., Maeda, T., Higashi, H., Ashizawa, S., Hatakeyama, M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  28. Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene. Handschug, K., Sperling, S., Yoon, S.J., Hennig, S., Clark, A.J., Huebner, A. Hum. Mol. Genet. (2001) [Pubmed]
  29. Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13. Claudio, J.O., Liew, C.C., Ma, J., Heng, H.H., Stewart, A.K., Hawley, R.G. Genomics (1999) [Pubmed]
  30. A highly conserved human gene encoding a novel member of WD-repeat family of proteins (WDR13). Singh, B.N., Suresh, A., UmaPrasad, G., Subramanian, S., Sultana, M., Goel, S., Kumar, S., Singh, L. Genomics (2003) [Pubmed]
  31. The WD-repeat protein GRWD1: potential roles in myeloid differentiation and ribosome biogenesis. Gratenstein, K., Heggestad, A.D., Fortun, J., Notterpek, L., Pestov, D.G., Fletcher, B.S. Genomics (2005) [Pubmed]
  32. The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3). Hopfer, U., Hopfer, H., Jablonski, K., Stahl, R.A., Wolf, G. J. Biol. Chem. (2006) [Pubmed]
  33. A genetic dissection of Aip1p's interactions leads to a model for Aip1p-cofilin cooperative activities. Clark, M.G., Teply, J., Haarer, B.K., Viggiano, S.C., Sept, D., Amberg, D.C. Mol. Biol. Cell (2006) [Pubmed]
  34. A spectroscopic analysis of the interaction between the human regulatory proteins RACK1 and Ki-1/57. Nery, F.C., Bressan, G.C., Alborghetti, M.R., Passos, D.O., Kuniyoshi, T.M., Ramos, C.H., Oyama, S., Kobarg, J. Biol. Chem. (2006) [Pubmed]
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