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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NECAP1  -  NECAP endocytosis associated 1

Homo sapiens

Synonyms: Adaptin ear-binding coat-associated protein 1, DKFZP566B183, NECAP endocytosis-associated protein 1, NECAP-1
 
 
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High impact information on NECAP1

  • One member of this family, NECAP 1, is found primarily in tissues from the central nervous system and has been shown to be complexed tightly with a substantial portion of adaptor protein-2 (AP-2) in brain extracts [1].
  • NECAP 1 was also detected by western blot in synaptic vesicle preparations [1].
  • We conclude from these observations that NECAP 1 plays a role in clathrin-mediated neuronal endocytosis, including a role in presynaptic endocytosis [1].
  • Additionally, we identified several new components of the machineries for clathrin-mediated membrane budding, including enthoprotin/epsinR and NECAP 1/2 [2].
  • Characterization of two of these proteins, NECAP1 and NECAP2, has led to the identification of a new consensus motif that mediates protein interactions with the clathrin adaptor protein 2 [3].

References

  1. Characterization of the localization and function of NECAP 1 in neurons. Murshid, A., Srivastava, A., Kumar, R., Presley, J.F. J. Neurochem. (2006) [Pubmed]
  2. Peptide motifs: building the clathrin machinery. McPherson, P.S., Ritter, B. Mol. Neurobiol. (2005) [Pubmed]
  3. Molecular mechanisms in clathrin-mediated membrane budding revealed through subcellular proteomics. Ritter, B., Blondeau, F., Denisov, A.Y., Gehring, K., McPherson, P.S. Biochem. Soc. Trans. (2004) [Pubmed]
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