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Gene Review

blaZ  -  beta-lactamase

Staphylococcus aureus

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Disease relevance of blaZ

  • The induction of the Staphylococcus aureus BlaZ and Bacillus licheniformis 749/I BlaP beta-lactamases by beta-lactam antibiotics occurs according to similar processes [1].

High impact information on blaZ

  • This gene fusion arrangement, which permitted monitoring of RepC production (as BlaZ activity) by plasmids using the protein for their own replication, demonstrated a linear relationship, with one exception, between RepC production and plasmid copy number over a 20-fold range [2].
  • A novel plasmid (designated pUB102) harbouring far1, tetK and blaZ was characterised and partially sequenced [3].
  • BlaZ could be transferred from the 4 isolates with plasmid location whereas it was not possible to transfer blaZ from 3 isolates with chromosomal location of the gene [4].


  1. The fate of the BlaI repressor during the induction of the Bacillus licheniformis BlaP beta-lactamase. Filée, P., Benlafya, K., Delmarcelle, M., Moutzourelis, G., Frère, J.M., Brans, A., Joris, B. Mol. Microbiol. (2002) [Pubmed]
  2. Measurement of gene expression by translational coupling: effect of copy mutations on pT181 initiator synthesis. Bargonetti, J., Wang, P.Z., Novick, R.P. EMBO J. (1993) [Pubmed]
  3. Microarray-based characterisation of a Panton-Valentine leukocidin-positive community-acquired strain of methicillin-resistant Staphylococcus aureus. Monecke, S., Slickers, P., Hotzel, H., Richter-Huhn, G., Pohle, M., Weber, S., Witte, W., Ehricht, R. Clin. Microbiol. Infect. (2006) [Pubmed]
  4. Occurrence of the blaZ gene in penicillin resistant Staphylococcus aureus isolated from bovine mastitis in Denmark. Vesterholm-Nielsen, M., Olhom Larsen, M., Elmerdahl Olsen, J., Moller Aarestrup, F. Acta Vet. Scand. (1999) [Pubmed]
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