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Gene Review

far1  -  Far1

Staphylococcus aureus

 
 
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High impact information on far1

  • Transformation of S. aureus with a construct containing a 949 bp far1-specific amplicon led to the isolation of a fusidic acid-resistant transformant, thereby identifying the pUB101 fusidic acid resistance structural gene [1].
  • Hybridization of Southern blots revealed that far1 was not located on the chromosome or plasmid content of a limited number of Australian, UK and Hong Kong fusidic acid-resistant isolates [1].
  • Sequencing of this fragment revealed three putative open reading frames (ORFs) of 213 (far1), 152 (orf152) and 170 amino acids (orf170), which are flanked by the right-hand end of insertion sequence IS431/257 (IS431/257RH) and a partial ORF [1].
  • A novel plasmid (designated pUB102) harbouring far1, tetK and blaZ was characterised and partially sequenced [2].
  • Most isolates showed resistance to tetracycline and fusidic acid because of the presence of the tetK and far1 genes [2].

References

  1. Genetic characterization of the fusidic acid and cadmium resistance determinants of Staphylococcus aureus plasmid pUB101. O'Brien, F.G., Price, C., Grubb, W.B., Gustafson, J.E. J. Antimicrob. Chemother. (2002) [Pubmed]
  2. Microarray-based characterisation of a Panton-Valentine leukocidin-positive community-acquired strain of methicillin-resistant Staphylococcus aureus. Monecke, S., Slickers, P., Hotzel, H., Richter-Huhn, G., Pohle, M., Weber, S., Witte, W., Ehricht, R. Clin. Microbiol. Infect. (2006) [Pubmed]
 
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