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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FBXL21  -  F-box and leucine-rich repeat protein 21...

Homo sapiens

Synonyms: F-box and leucine-rich repeat protein 21, F-box and leucine-rich repeat protein 3B, F-box/LRR-repeat protein 21, F-box/LRR-repeat protein 3B, FBL21, ...
 
 
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Disease relevance of FBXL21

  • In vivo efficacy of human IL-2 was demonstrated in increasing alloantigen responsiveness and in increasing the efficacy of transferred expanded immune lymphocytes in the FBL-3 lymphoma model [1].
  • Retroviral vectors were used to transiently transduce C8, a CD4(+) T cell clone that specifically recognized FBL-3, a lethal myeloid leukemia [2].
 

High impact information on FBXL21

  • Immunoregulatory alpha-globulin (IRA) derived from normal human plasma decreased cytotoxic reactivity as measured by an in vitro 5-iodo-2'-deoxyridine release assay of immune mouse lymphocytes against the syngeneic Friend virus-induced leukemia, FBL-3 [3].
  • Similar studies of cytotoxic reactivity to a syngeneic FBL-3 lymphoma have given rise to long-term cytotoxic cell lines growing in TCGF capable of curing mice with disseminated lymphoma in adoptive transfer studies [4].

References

  1. In vivo administration of purified Jurkat-derived interleukin 2 in mice. Donohue, J.H., Lotze, M.T., Robb, R.J., Rosenstein, M., Braziel, R.M., Jaffe, E.S., Rosenberg, S.A. Cancer Res. (1984) [Pubmed]
  2. Retroviral immunotoxin gene therapy of leukemia in mice using leukemia-specific T cells transduced with an interleukin-3/Bax fusion protein gene. Vallera, D.A., Jin, N., Shu, Y., Panoskaltsis-Mortari, A., Kelekar, A., Chen, W. Hum. Gene Ther. (2003) [Pubmed]
  3. In vitro inhibition of cell-mediated cytotoxicity against syngeneic Friend virus-induced leukemia by immunoregulatory alpha globulin. Glaser, M., Ting, C.C., Herberman, R.B. J. Natl. Cancer Inst. (1975) [Pubmed]
  4. Development of long-term cell lines and lymphoid clones reactive against murine and human tumors: a new approach to the adoptive immunotherapy of cancer. Rosenberg, S.A., Eberlein, T.J., Grimm, E.A., Lotze, M.T., Mazumder, A., Rosenstein, M. Surgery (1982) [Pubmed]
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