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Gene Review

PLA2G2D  -  phospholipase A2, group IID

Homo sapiens

Synonyms: GIID sPLA2, Group IID secretory phospholipase A2, PLA2IID, Phosphatidylcholine 2-acylhydrolase 2D, SPLASH, ...
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Disease relevance of PLA2G2D

  • Based on the degree of erythema, the least irritation was produced with Sesame Street Fresh Apple Splash bubble bath [1].
  • 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema, in which the expression of sPLA(2)-IID, -IIF and -V was increased, was significantly reduced by YM-26734, a competitive sPLA(2)-IIA inhibitor that turned out to inhibit sPLA(2)-IID, -IIE, -V and -X as well [2].

High impact information on PLA2G2D

  • The genomic structure indicated that most of the PLA2G2D transcripts are formed by four exons [3].
  • We reassembled trace files available from the Whole Genome Sequencing (WGS) Project, obtaining an 86-kb contig with three tandem PLA2G2D duplications in the Hereford strain [3].
  • In lipopolysaccharide (LPS)-treated mice, the expression of sPLA(2)-V, and to a lesser extent that of sPLA(2)-IID, -IIE, and -IIF, were increased, whereas that of sPLA(2)-X was rather constant, in distinct tissues [2].


  1. Comparison testing of the irritancy of children's liquid bubble bath using a modified human repeat insult patch test. West, N.Y., Fitzpatrick, J.E., Jackson, E.M. Am. J. Contact Dermatitis (1998) [Pubmed]
  2. Induction of distinct sets of secretory phospholipase A(2) in rodents during inflammation. Hamaguchi, K., Kuwata, H., Yoshihara, K., Masuda, S., Shimbara, S., Oh-ishi, S., Murakami, M., Kudo, I. Biochim. Biophys. Acta (2003) [Pubmed]
  3. Accelerated expansion of group IID-like phospholipase A2 genes in Bos taurus. Golik, M., Cohen-Zinder, M., Loor, J.J., Drackley, J.K., Band, M.R., Lewin, H.A., Weller, J.I., Ron, M., Seroussi, E. Genomics (2006) [Pubmed]
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