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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GBAS  -  glioblastoma amplified sequence

Homo sapiens

Synonyms: Glioblastoma-amplified sequence, NIPSNAP2, NipSnap2, Protein NipSnap homolog 2
 
 
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High impact information on GBAS

  • GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR [1].
  • The GBAS transcript is 2.2 kb in length and contains an 858-bp open reading frame [1].
  • Here we report the identification of and coding sequence for a novel gene, GBAS, that is localized to this region and was found to be amplified in 2 of 12 tumors as well as in 2 of 3 cell lines with EGFR amplification [1].
  • The second human gene, NIPSNAP2, is localized in the vicinity of marker D7S499 on chromosome 7 [2].

References

  1. GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR. Wang, X.Y., Smith, D.I., Liu, W., James, C.D. Genomics (1998) [Pubmed]
  2. Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family. Seroussi, E., Pan, H.Q., Kedra, D., Roe, B.A., Dumanski, J.P. Gene (1998) [Pubmed]
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