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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GBP2  -  guanylate binding protein 2, interferon...

Homo sapiens

Synonyms: GBP-2, GTP-binding protein 2, Guanine nucleotide-binding protein 2, HuGBP-2, Interferon-induced guanylate-binding protein 2
 
 
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High impact information on GBP2

  • Among the most abundant antiviral proteins induced by interferon-gamma are guanylate-binding proteins such as GBP1 and GBP2 [1].
  • Of these, five are similar to ETS (expression tagged sequences) from unknown genes; the other two show significant homology to the cDNAs of ubiquitin and human guanylate binding protein 2 (GBP-2) [2].
  • Analysis of the additional costs to the NHS, depending on the rate of change from benzodiazepine prescriptions to Z-drug prescriptions, at current levels of hypnotic prescribing, range from GBP2 million to GBP17 million per year [3].
 

Biological context of GBP2

  • Both hGBP1 and hGBP2 failed to hydrolyze GDP, however, GDP was an effective inhibitor of the hGBP2- but not the hGBP1-catalyzed GTP hydrolysis reaction [4].
 

Other interactions of GBP2

  • Our data suggest that the GBP family of genes contains members other than the previously characterized GBP1 and GBP2 [5].

References

  1. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. Prakash, B., Praefcke, G.J., Renault, L., Wittinghofer, A., Herrmann, C. Nature (2000) [Pubmed]
  2. Differential display RT PCR of total RNA from human foreskin fibroblasts for investigation of androgen-dependent gene expression. Nitsche, E.M., Moquin, A., Adams, P.S., Guenette, R.S., Lakins, J.N., Sinnecker, G.H., Kruse, K., Tenniswood, M.P. Am. J. Med. Genet. (1996) [Pubmed]
  3. Newer hypnotic drugs for the short-term management of insomnia: a systematic review and economic evaluation. Dündar, Y., Boland, A., Strobl, J., Dodd, S., Haycox, A., Bagust, A., Bogg, J., Dickson, R., Walley, T. Health technology assessment (Winchester, England) (2004) [Pubmed]
  4. GTPase properties of the interferon-induced human guanylate-binding protein 2. Neun, R., Richter, M.F., Staeheli, P., Schwemmle, M. FEBS Lett. (1996) [Pubmed]
  5. The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1. Strehlow, I., Lohmann-Matthes, M.L., Decker, T. Gene (1994) [Pubmed]
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