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Gene Review

Gbp2  -  guanylate binding protein 2

Mus musculus

Synonyms: GBP-2, GTP-binding protein 2, Guanine nucleotide-binding protein 2, Interferon-induced guanylate-binding protein 2, mGBP-2, ...
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Disease relevance of Gbp2

  • Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain [1].

High impact information on Gbp2

  • Finally, NIH 3T3 cells expressing mGBP-2 formed tumors in athymic mice [2].
  • An mGBP-2 protein carrying a point mutation (S52N) that reduced GTP binding failed to produce these phenotypes when expressed at the same levels as wild type [2].
  • The additional finding that IFN-gamma treatment of NIH 3T3 cells resulted in an increase in proliferation similar to that observed for mGBP-2 in the absence of other IFN-induced proteins suggests that mGBP-2 may indeed be important for these growth changes [2].
  • The genomic organizations of the genes encoding mGBP1 and mGBP2 are similar, and the nucleotide sequences of their IFN-responsive-like elements and their relative locations are conserved [3].
  • First, mGBP-2 contains only two of the three consensus sequences for nucleotide binding found within the classic GTP binding regions of other GTPases [4].

Biological context of Gbp2


Analytical, diagnostic and therapeutic context of Gbp2

  • Sequence analysis of the gene encoding this newly identified RNA reveals that in its 5'-region it is identical to a DNA fragment reported to represent the 5'-region of a gene termed mGBP2 [3].


  1. Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain. Carter, C.C., Gorbacheva, V.Y., Vestal, D.J. Arch. Virol. (2005) [Pubmed]
  2. The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation. Gorbacheva, V.Y., Lindner, D., Sen, G.C., Vestal, D.J. J. Biol. Chem. (2002) [Pubmed]
  3. Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family. Anderson, S.L., Carton, J.M., Zhang, X., Rubin, B.Y. J. Interferon Cytokine Res. (1999) [Pubmed]
  4. Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages. Vestal, D.J., Buss, J.E., McKercher, S.R., Jenkins, N.A., Copeland, N.G., Kelner, G.S., Asundi, V.K., Maki, R.A. J. Interferon Cytokine Res. (1998) [Pubmed]
  5. Non-pathogenic bacteria modulate colonic epithelial gene expression in germ-free mice. Fukushima, K., Ogawa, H., Takahashi, K., Naito, H., Funayama, Y., Kitayama, T., Yonezawa, H., Sasaki, I. Scand. J. Gastroenterol. (2003) [Pubmed]
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